Pharmacovigilance – News and Features

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Evotec Phase I Safety and Tolerability Study with EVT 302 Successfully Completed
The study was aimed at investigating safety/tolerability, pharmacokinetics, and pharmacodynamics during prolonged dosing with EVT 302 as compared to placebo.

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GlaxoSmithKline and Theravance Start Large Phase 2B ICS and LABA Studies for Asthma in the Horizon Programme
Compound 642444 and compound 685698 advance in clinical development for the treatment of asthma.

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International Stem Cell Corp. Creates Human Stem Cell Lines that can Eliminate Immune Rejection by Patients
Discovery is a step closer to a universal stem cell line for human therapeutics and creation of a global stem cell bank.

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Stealth Biotech launched to commercialize technology based on targeting specific microRNA:mRNA interactions.
Stealth Biotech announced today its plans to target specific microRNA:mRNA interactions for development of novel oligonucleotide-based therapeutics.

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Evotec to Acquire Renovis, Seek NASDAQ Listing
Evotec AG and Renovis, Inc. today announced that they have entered into a definitive agreement under which Evotec will acquire Renovis, a biopharmaceutical company focused on the discovery and development of drugs for major medical needs in the areas of pain and inflammatory diseases, in a stock-for-stock transaction valued at approximately US$ 151.8 million.

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New Drug Combination is Able to Eradicate Breast Metastases in Mice
Southern Illinois University’s researchers presented the results of a study using nab-paclitaxel and bevacizumab to treat lymphatic and pulmonary metastases in female SCID mice.

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Synthetic Blood Announces Oxycyte Development Strategy
The Company finalized its Phase IIb Oxycyte clinical trial and plans to initiate three pre-clinical animal studies in sickle cell disease, spinal cord injury and stroke in the first half of 2008.

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Millipore Corporation and Novozymes Form Strategic Alliance to Supply Animal-Free Cell Culture Supplements for Bioprocessing
Alliance will accelerate launch of new animal-free supplements and provide customers with a source of high performance cell culture products.

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University of Kentucky Creates Cancer-Resistant Mouse
A mouse resistant to cancer, even highly-aggressive types, has been created by researchers at the University of Kentucky. The breakthrough stems from a discovery by UK College of Medicine professor of radiation medicine Vivek Rangnekar and a team of researchers who found a tumor-suppressor gene called "Par-4" in the prostate.

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Brain Stem Cells Sensitive to Space Radiation
Measures to protect astronauts from health risks caused by space radiation will be important during extended missions to the moon or Mars, say researchers.
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