Pharmacovigilance – News and Features
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Common Lung Scarring Treatment Extends Ovarian Function in Older Mice
Researchers found that the drug Pirfenidone can reduce ovarian fibrosis in aging mice, improving follicle counts and hormone levels. This study aims to extend ovarian healthspan and address issues related to aging.
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Post-Surgery Immunotherapy Helps People With High-Risk Bladder Cancer Live Longer Cancer-Free
Researchers found that the immunotherapy drug pembrolizumab significantly extends the cancer-free period for patients with high-risk muscle-invasive bladder cancer after surgery.
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High-Dose Amphetamines Linked to Increased Risk of Psychosis and Mania
A study reveals that high doses of prescription amphetamines, like dextroamphetamine, are linked to a more than five-fold increased risk of developing psychosis or mania. The findings suggest caution is needed when prescribing these medications.
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Majority of Pediatric Long COVID Patients Develop Orthostatic Intolerance
The majority of children diagnosed with long COVID are likely to experience orthostatic intolerance, a condition that causes the body to struggle with regulating blood pressure and heart rate when standing up.
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Dual Immunotherapy Extends Prostate Cancer Survival by 33 Months
A study shows that immunotherapy effectively slows prostate cancer progression by 33 months in men with specific genetic mutations. Targeted subtypes MMRd, hTMB, BRCAm, and CDK12i show the most promise.
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Advanced Melanoma Survival Dramatically Improves With Immunotherapy
A 10-year follow-up of the CheckMate 067 trial shows that around half of metastatic melanoma patients treated with nivolumab and ipilimumab are cancer-free after a decade. The study confirms long-term efficacy and safety of the combination therapy.
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Experimental mRNA Cancer Vaccine Shows Promise in Patients With Advanced Cancers
Interim data from the Phase I dose escalation part of the mRNA cancer immunotherapy (mRNA-4359), show promise in patients with advanced solid cancers.
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Trastuzumab Deruxtecan Effective Against Brain Metastases in Advanced Breast Cancer
The DESTINY-Breast12 trial revealed that trastuzumab deruxtecan (T-DXd) effectively targets brain metastases in HER2-positive breast cancer. T-DXd offers a promising new option for patients with advanced disease.
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High Doses of Some Stimulants Can Increase Psychosis Risk
Individuals who are taking high doses of amphetamine (e.g., Adderall) face more than a five-fold increased risk for developing psychosis or mania.
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Promising Lassa Fever Vaccine Prevents Disease and Death in Preclinical Animal Models
Researchers developed the LASSARAB vaccine, using a deactivated rabies virus to protect against Lassa fever. In preclinical trials, it prevented severe disease and death in animals.
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