Screening Strategies in Drug Discovery – Multimedia

With growing concerns over a multitude of food risks, accurate and sensitive analytical tools are needed to ensure food safety. Liquid chromatography-mass spectrometry (LC-MS) has become an indispensable method for food safety testing and quality control, capable of detecting and quantifying even trace amounts of numerous contaminants and harmful species in food.

Since the earliest microscopy efforts in the 1600s, cell imaging has significantly modernized and become a ubiquitous tool in cell biology laboratories. Here, we cover five key advances in cell microscopy to help you understand how the field is progressing.

Download this app note to discover a system that provides high-speed and reproducible quantification, has broad compound coverage and is purpose built for incorporation into high-throughput screening workflows.

Download this guide to learn how you can generate uniform 3D cell models, get the best quality images, minimize imaging time and volume of data as well as avoid unnecessary data transfer steps.

Access this whitepaper to discover a system that performs virtual screening at ultra-high-throughput scale, requires minimal costs and can be run with cloud computing or HPC resources.

Download this poster to discover how ITC requires minimal assay development and sample preparation, allows early determination and elimination of false positives and can be used to identify fragments that will form a high-resolution co-crystal with the target protein.

Fragment-based drug discovery (FBDD) is one of the most popular approaches for finding lead compounds and it is becoming more widely adopted by pharma companies. Access this eBook to learn about the advantages, applications and future prospects of FBDD.

Download this app note to discover an example that shows pooling crRNAs to the same gene target provides robust functional knockout and reveal ways to ensure crRNA pools work successfully in phenotypic screening.

Download this app note to learn more about automated patch clamp and the benefits of using it in drug discovery.

In this infographic, we review the history of fragment-based drug discovery, discuss the underlying concepts and examine the process in more detail.