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Screening Strategies in Drug Discovery – News and Features

Confocal image of a CHOOSE (CRISPR-human organoids-scRNA-seq) human brain.
News

How Human Brain Organoids Are Uncovering the Cause of Autism

With a revolutionizing novel system that combines brain organoid technology and intricate genetics, researchers can now comprehensively test the effect of multiple mutations in parallel and at a single-cell level within human brain organoids.
DNA double helix scribbles.
Article

The Potential for Groundbreaking Discoveries With CRISPR Screening

In this article, we consider various platforms to modulate gene expression and the potential of CRISPR-Cas systems to understand and treat diseases, from cancers and congenital disorders to overcoming the growing prevalence of antimicrobial resistance.
Four types of medicinal tablets.
News

Drug Screening Helps Identify Effective Therapeutic Strategies for Pediatric Cancer

In a landmark study of 125 Australian children with high-risk cancer, researchers have found that they can improve the chances of finding the right drug to kill their individual cancer through a new system of rapid drug screening.
A 3D map and a 3D model of a protein structure generated using cryo EM.
Article

Cryo Electron Microscopy: Principle, Strengths, Limitations and Applications

Cryo electron microscopy (cryo EM) has revolutionized our understanding of the intricate molecular machinery that governs life. In this article, we discuss what cryo EM is, how it works, it's strengths, limitations and applications.
Computer-generated image of nerve cells.
News

Mouse Study Raises Possibility of ALS Immunotherapy Treatment

Researchers have modulated a protein related to the immune system to slow the progress of amyotrophic lateral sclerosis (ALS) in mice.
Cancer cells.
News

Promising Early Trial Results for Second-Generation Cancer Therapy

Preliminary results of a study show that a novel, selective inhibitor of protein arginine methyltransferase 5 demonstrated antitumor activity in patients with advanced malignant solid tumors or B cell non-Hodgkin lymphomas.
An orange pill bottle spilling pills in a variety of sizes, shapes and colors.
News

Potential New Therapies To Lower “Bad” Cholesterol Discovered

A group of molecules with the potential to treat familial hypercholesterolemia, a genetic disease that causes high cholesterol levels, has been identified in a new study.
A picture of medicines.
Industry Insight

Failing Faster To Succeed Sooner in Drug Discovery

Revvity announced its newly established Scientific Centre of Excellence in Cambridge, where scientists can outsource their research needs to Revvity experts. Technology Networks visited the site to learn more about how Revvity is supporting its customers in their drug discovery efforts.
Pink tablets in a blister pack.
News

Existing Cancer Drug May Be Repurposed for Other Aggressive Cancers

A team of researchers has identified an existing cancer drug that could also be used to treat an aggressive subset of cancers.
Lipid nanoparticle mRNA vaccine.
Article

High-Throughput Formulation Screening To Fine-Tune Performance Characteristics of Nanomedicines

This article discusses how marrying microfluidics with automation can provide the necessary level of control to perform high‑throughput LNP formulation screening in a cost-effective and timely manner, and how this approach can accelerate the development of new nanomedicines.
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