Spatial Biology – News and Features

Immuno-oncology and cell-based treatments, which harness the body's own immune system to combat illnesses like cancer, have emerged as some of the most promising areas of study. This article explores how cell therapy is evolving.

Colorectal cancer and pancreatic ductal adenocarcinoma that harbored the KRAS G12C mutation often carried other genetic alterations that can be associated with resistance to KRAS G12C inhibitors.

New research has uncovered a mechanism by which brain cancer cells reprogram immune cells from fighting cancer to enabling tumor growth.

A deep-learning framework can support spatial transcriptomics techniques by integrating gene expression, spatial data and histological images to advance tissue analysis.

While controlling swelling caused by brain cancer is important, a new study shows that a commonly prescribed anti-swelling drug suppresses the immune system for weeks after dosage, inhibiting the body’s ability to fight the cancer.

Researchers find four coordinated gene expression programs in immune cells from glioma tumors, including two that could lead to immunotherapy resistance.

Researchers from New York University have uncovered that cancer cells also work together to source nutrients from their environment — a cooperative process that was previously overlooked but may be a promising target for treating cancer.

Scientists have discovered a novel subset of cancer-fighting immune cells that reside outside of their normal neighborhood – known as the tertiary lymphoid structure – where they become frustratingly dysfunctional when in close contact with tumors.

Researchers have discovered that stomach cancers make electrical connections with nearby sensory nerves and use these malignant circuits to stimulate the cancer’s growth and spread.

Researchers at The Jackson Laboratory created an aging breast tissue atlas, revealing how genetic and molecular shifts may increase cancer risk. Changes in epithelial, immune and stromal cells create a tumor-friendly microenvironment.