Spatial Biology – News and Features

A new framework has used neural network training dynamics to interpret single-cell and spatial omics data.

St. Jude researchers reveal that moderate levels of mitochondrial DNA mutations boost leukemia growth by increasing metabolic plasticity, while high mutation levels shut down tumor development.

Researchers developed a dual-vector "zip-sorting" system, doubling the genetic capacity of CAR T cells to combat tumor resistance. This enables T cells to target multiple antigens, reduce exhaustion via switch receptors and resist immune suppression.

Hear from an early user of the neofleXTM MALDI-TOF instrument about how the technology adds new capabilities to MSI workflows.

In a new study, scientists combined strategies to deliver energy-disrupting gene therapy using nanoparticles manufactured to zero in only on cancer cells, with experiments showing the targeted therapy effective in mice.

Professor Jennifer Van Eyk joined Technology Networks for an exclusive interview at HUPO 2024 to discuss progress and bottlenecks in clinical proteomics

University of Alabama researchers reveal a key mechanism in BK polyomavirus replication, challenging existing models. The virus relies on host cell DNA replication, with its TAg protein expressed only after the first replication round.

University of Michigan researchers identified UBA1 as a key player in immunotherapy resistance. Inhibiting UBA1 boosts T-cell recruitment, converting cold tumors to hot, and enhancing the effectiveness of immune checkpoint blockade therapies.

Researchers discovered that starlet sea anemones reshape their entire bodies during regeneration to maintain their original proportions. Using spatial transcriptomics, the team identified enzymes active throughout the body that realign tissues.

Researchers discovered that tumors grow uniformly throughout their mass, challenging the idea of faster growth at edges. Spatial genomics and simulations revealed evenly distributed mutations within tumors.