Spatial Biology – News and Features

The HUMANOID Center at UC San Diego is pioneering organoid research aimed at improving the reliability and reproducibility of these models, ultimately increasing drug testing accuracy and revolutionizing biomedical science.

Researchers found that nutrient starvation, not persister cells, helps Salmonella survive antibiotic treatments. Using real-time tracking, they demonstrated that nearly all Salmonella in infected tissues resist antibiotics due to slow growth.

This article explores methods to enhance efficiency in the drug discovery and development pipeline, focusing on optimizing processes and exploring innovations that could streamline the path from research to approval.

Scientists developed a novel method to grow T cells that survive longer and fight cancer more effectively. By altering their metabolism, these lab-grown T cells resisted melanoma for nearly a year in mice, offering new hope for cell therapies.

Dana-Farber researchers identified factors predicting the success of donor lymphocyte infusion (DLI) in treating relapsed AML. They found that specific CD8+ T cells with high ZNF683/Hobit expression are crucial for the therapy’s efficacy.

Research from VIB-UGent identifies lipid-associated macrophages and LAM-like Kupffer cells as critical for liver repair. The study reveals TREM2's role in clearing damaged cells and promoting recovery.

Self-supervised AI could offer a promising approach for analyzing 20 million cells or more.

Pathogen-fighting immune cells go through a surprising transformation and relocation as they fight infections in the gut.

A contact protein printing technique enables researchers to control the formation of villi in human gut models, making it possible to study key cellular processes and disease-associated changes.

Combining long-read DNA sequencing with a predictive artificial intelligence model has provided new insights into DNA replication.