Structural Biology – News and Features

Researchers mapped HIV-1’s translation strategy, revealing RNA elements like uORFs, iORFs and an intricate frameshift site structure that regulate viral protein synthesis. These findings highlight ribosome pausing as a key mechanism.

Researchers have determined the 3D structure of SAMURI, an artificial ribozyme that precisely modifies RNA. Using S-adenosylmethionine (SAM) as a cofactor, SAMURI catalyzes targeted RNA changes critical for cellular function.

Researchers use data from protein shapes, combined with data from genomic sequences, to improve the reliability of evolutionary trees, a critical resource used by the scientific community for understanding the history of life.

A new AI tool can accurately predict gene activity within any human cell, revealing the cell's inner mechanisms.

ECRC researchers developed a CRISPR-based gene therapy targeting dysferlin mutations in muscular dystrophy. By editing and transplanting corrected muscle stem cells, they restored protein function and regrew muscle in preclinical models.

Researchers at Ruhr University Bochum discovered that a lipid anchor on nerve cell membranes stabilizes prion protein folding, preventing harmful aggregation linked to prion diseases.

The harmless bacteria that cluster around plant roots can influence the plant's balance of growth and defense, a new study has found.

The SIMPL2 platform, developed by University of Toronto researchers, simplifies and improves protein interaction measurement, crucial for understanding disease mechanisms and developing drug therapies.

Cancer Research Horizons and Diamond Light Source aim to strengthen their partnership, combining their expertise and resources to bring new cancer treatments to patients.

Parag Mallick, Stanford scientist and Nautilus co-founder, is looking to transform proteomics with a platform for proteome-wide analysis, advancing diagnostics and disease research.