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The Immune System – Multimedia

6 Ultra-Low Cost Diagnostics content piece image
Listicle

6 Ultra-Low Cost Diagnostics

In this list we look at 6 promising ultra-low cost diagnostic technologies, which could help take the tools to where they are most needed.
Vaccines in the 21st Century content piece image
Infographic

Vaccines in the 21st Century

Learn how vaccines have been saving lives since 1798 and continue to do so in the 21st Century thanks to the cutting-edge science underlying their development.
Investigating the Effects of Fructose Consumption and Inadequate Copper Intake on Nonalcoholic Fatty Liver Disease content piece image
Poster

Investigating the Effects of Fructose Consumption and Inadequate Copper Intake on Nonalcoholic Fatty Liver Disease

Metabolomics is a viable method for identifying compounds associated with NAFLD. In this investigation, high-quality data facilitate the identification of key metabolites differentiating normal versus diseased species.
MHV68 Infection in a Novel rag2 F62L/F62L Mouse Model Based on a Patient with CID-G/AI Phenotype  content piece image
Poster

MHV68 Infection in a Novel rag2 F62L/F62L Mouse Model Based on a Patient with CID-G/AI Phenotype

MHV-68 infection in our rag2 mouse model induced increased antibody responses to virus and self and inflammatory disease in end organs. Major mechanism of inflammatory infiltrates and autoantibody generation is yet to be determined
Amyloid Beta Nano Particle used to Sensitize Dendritic Cells as a Therapeutic Vaccine against Alzheimer's disease content piece image
Poster

Amyloid Beta Nano Particle used to Sensitize Dendritic Cells as a Therapeutic Vaccine against Alzheimer's disease

This project researches the use of immunotherapy to combat Alzheimer's disease. This is achieved by exposing dendritic cells, antigen presenting cells, to amyloid beta in order to sensitize the cell. The results indicate that a mutant form of amyloid beta was successful in producing anti-amyloid-beta antibodies and in improving behavior in the mice.
An Antitumor Antibody Response to Attenuate Metastatic Melanoma in a Murine Model content piece image
Poster

An Antitumor Antibody Response to Attenuate Metastatic Melanoma in a Murine Model

These preliminary results show antitumor activity of adoptive cell transfer of MHC class mismatched CD4(+) T-cells. The finding of reduced numbers of pulmonary metastases correlates with increased serum anti-OVA IgG and increased germinal center development in the spleen.
Astaxanthin Attenuates Neurotoxicity in a Mouse Model of Parkinson’s disease content piece image
Poster

Astaxanthin Attenuates Neurotoxicity in a Mouse Model of Parkinson’s disease

Both oxidative stress and inflammation are involved in the progression of many neurodegenerative diseases, therefore, we examined the potential for AXT to reduced neurotoxicity in a toxic model of PD in mice. Here, we show that administration of algae derived AXT mitigated MPTP induced dopamine cell death.
Discrepancy between TRPA1 Activation by Reversible and Irreversible Electrophiles Suggests Involvement of Cytosolic Cofactors Other Than Polyphosphates content piece image
Poster

Discrepancy between TRPA1 Activation by Reversible and Irreversible Electrophiles Suggests Involvement of Cytosolic Cofactors Other Than Polyphosphates

Electrophiles can bind through reversible or irreversible reactions based on the structure of the compound. Here, patch clamp techniques and calcium imaging have been used to characterize human TRPA1 (hTRPA1) channel activity (expressed in HEK293 cells) in the presence of reversible and irreversible electrophiles
Neuroprotection by T-Lymphocytes and Stem Cells After Ischemic Stroke content piece image
Poster

Neuroprotection by T-Lymphocytes and Stem Cells After Ischemic Stroke

In this study, regulatory T-cells and BMSCs were shown to be neuroprotective following ischemic treatment of primary rat neurons.
Role of TDP-43 in activation of the brain inflammatory response content piece image
Poster

Role of TDP-43 in activation of the brain inflammatory response

Profiling of inflammatory cytokines, receptor and kinases in WT and TDP-43 overexpressing mice.
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