Better mRNA-LNPs: Encapsulation Efficiency, mRNA Integrity and Purity, Lipid N-Oxides and Beyond
Lipid nanoparticles (LNPs) have emerged as a popular delivery vehicle for gene therapy and vaccines due to their ability to scale up and versatility to encapsulate various sizes of genetic material, amongst other factors. However, LNPs consisting of helper lipids, PEGylated lipids and ionizable lipids can be susceptible to N-oxide-based impurities that can cause the loss of function of the genetic payload.
To ensure the safety and efficacy of LNP-based drugs, comprehensive characterization of these sophisticated molecules–the lipids and the genetic cargo–is paramount.
Watch this webinar to:
- Learn why process-related lipid impurities are a concern for therapeutics and vaccines
- Discover how to achieve detailed structural characterization of ionizable lipids and their impurities
- Explore how to break through limitations of intact mRNA analysis with intuitive, kit-based solutions that offer high-quality integrity and purity results for a wide range of sizes
- Take control of determining mRNA-LNP encapsulation efficiency with an intuitive capillary electrophoresis workflow