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Reimagining Micro and Macro Chemical Workflows for Improved Communication

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Known as the “central science”, chemistry is essential to virtually all scientific disciplines.

Communicating information about millions of known, and even more unknown, chemical compounds, in an accurate, digestible, and elegant manner is essential to documenting the reproducibility and transparency of your research

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10 Things We Didn't Know Last Week – 10 May 2019

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A wrap-up of the biggest science news from the last 7 days.

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The Gallbladder, Bile Ducts and Associated Cancers

Video

A guide to the gallbladder and bile ducts, including where they are, what they do and the different areas that cancer can develop.

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Broccoli Compound Restores Potent Cancer Cell Suppressor Function
News

Researchers report that indole-3-carbinol (I3C) – a natural compound found in broccoli – can be used to therapeutically target a gene (WWP1) known to play a role in several human cancers.

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A Bite Out of the Blood-brain Barrier
News

Molecules from the immune system of a jawless parasitic fish could help lead the way to more effective treatments for multiple brain ailments, including cancer, trauma and stroke.



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Specialized Microscope Scans and Closes Single Blood Vessels
News

If further developed, this specialized microscope could be revolutionary for the treatment of skin cancer, as it enables incredibly precise surgery – all without cutting skin.

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“Metabolic Fingerprint” Could Help Treat, Diagnose and Prevent Cervical Cancer
News

Researchers at the University of Arizona have completed the first-of-its-kind study that could aid in the treatment, diagnosis and prevention of cervical cancer by identifying cervicovaginal metabolic signatures, or "fingerprints" that distinguish patients with HPV, pre-cancerous cervical conditions and cancer.

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Why Do Hodgkin's Lymphoma Cells Grow Uncontrollably?
News

A team at the Max Delbrück Center led by Professor Claus Scheidereit has now identified an important signaling molecule in the biology of Hodgkin's lymphoma: LTA. It helps the cancer to grow unimpeded – for example, by activating genes for immune checkpoint ligands that protect tumor cells from the body’s built-in defense system.

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Conquering Cancer’s Infamous KRAS Mutation
News

Scientists from Sanford Burnham Prebys and PHusis Therapeutics have shown that a compound called PHT-7.3 shrinks KRAS-driven tumors in mice.

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The First Winners of the LEA
Article

The Lipidomics Excellence Award (LEA) was founded to strengthen life sciences through lipidomics. After reviewing the many high-quality submitted projects, the LEA jury has announced the three awardees.

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Whole-Exome Sequencing at the Dawn of Personalized Medicine
Article

Deciphering the first complete sequence of the human genome in 2003 required a combined effort of scientists from 20 institutions and $3 billion of funding. Over the last decade, whole-exome sequencing (WES) established itself as a method that successfully balances cost and the output of useful data for diagnostic or research applications. Here, we look at how WES is used in both the laboratory and the clinic, and why it is a preferred method of choice in such areas.

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Antibodies in Research: The Good, the Bad, and the Validation Epidemic
Article

The specificity of antibody binding is incredibly important for many research disciplines, yet sourcing the best antibody for your research can be a challenge. This is partly because not all suppliers validate their antibodies sufficiently. How much of a problem is this?

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The Evolving Field of Cancer Biomarkers
Article

Given the complexity of cancer, it’s arguably unlikely that single molecules will work as clinically meaningful biomarkers for cancer. Today, biomarker discovery involves detecting patterns – characteristics or phenotypes that can be measured and monitored throughout a patient’s journey. Here, we look at two approaches being explored in this evolving field.

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Sensitivity vs Specificity
Article

When developing diagnostic tests or evaluating results, it is important to understand how reliable those tests and therefore the results you are obtaining are. By using samples of known disease status, values such as sensitivity and specificity can be calculated that allow you to evaluate just that.

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Preclinical Modeling of Tumor Metastasis and Resistance: Current Challenges and New Approaches
Article

To improve cancer survival rates, pharma and biotech researchers must develop safe and effective therapies to treat not only primary tumors, but also metastatic growths and tumors that have acquired resistance.

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