Latest App Notes & Case Studies

Studying DNA methylation at correlated gene regions can provide researchers with insights into disease-associated epigenetic variation. Hence, cost-effective sequencing is essential for our advancement and understanding of epigenetic epidemiology.

Formalin-fixed, paraffin-embedded (FFPE) tissue is a valuable resource in the retrospective proteomic analysis of clinical and non-clinical samples. However, sample preparation techniques typically involve laborious, time-consuming and potentially hazardous xylene-based deparaffinization steps.

CAR-T cell therapy has emerged as one of the most promising novel treatments in the fight against cancer.

Metabolism is a key driver of CAR-T cell fitness and function. Hence, metabolic preconditioning methods can enhance the bioenergetic capacity of CAR-T cells in culture, supporting their persistence and antitumor activity

Download this app note to learn how you can select 20 individual CTCs in 10 minutes, this approach can be used for DNA, RNA or proteome analysis as well as how these target cells are selected and isolated in high purity from heterogenous backgrounds.

Metabolism has emerged as a key driver of T-cell antitumor function. This means that modulating metabolic programs of T cells can be used as a strategy to improve the antitumor efficacy of adoptive T-cell therapies.

Data-independent acquisition (DIA) has been shown to increase the quantitative reproducibility and accuracy of MS-based phosphoproteomics. This app note explores the impact of dia-PASEF on the speed and sensitivity of phosphoproteomics.

As oligonucleotides (oligos) are synthesized, small amounts of impurities can be introduced at each step, and different synthesis methods and purification efficiencies can impact the quality of the sample.

From vaccines to gene therapies, RNA produced by in vitro transcription (IVT) has many therapeutic applications.

Single cell and spatial technologies that profile gene expression across whole tissues are revolutionizing the resolution of molecular states in clinical tissue samples.