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Latest Application Notes

Application Note

Development of a Targeted Plasma Quantitation Assay Using dia-PASEF

In clinical proteomics research applications, blood plasma is the key sample of interest, but comprehensive proteome analysis can be challenging due to the large dynamic range of concentration.
Application Note

Progress Towards Out-of-the-Box Sub-Cellular Imaging

Single cell analysis in a spatially resolved context is the gateway to deciphering scientific questions in various application areas. Such analysis requires the highest available spatial precision combined with highly sensitive detection.
Application Note

Expansion of Specific Lymphocyte Populations

Expansion of Specific Lymphocyte Populations With 4CellĀ® Nutri-T Xeno-Free, Serum-Free Medium

The success of CAR T-cell therapy requires efficient expansion of specific subpopulations of patient-derived immune cells.
Application Note

mAb Quantitation: Protein A HPLC vs Protein A Bio-Layer Interferometry

There are currently more than 140 monoclonal antibodies (mAbs) approved by the FDA as biotherapeutic agents, representing the most rapidly growing class of new drugs.
Application Note

Label-Free Single Cell Proteomics Workflow

Label-Free Single Cell Proteomics Workflow With the CellenONE Platform and the TimsTOF SCP
Application Note

Are You Compliant When it Comes to Pipetting?

During pharmaceutical development and manufacturing, there is always the question: are you following methods for current good laboratory practice or current good manufacturing practice?
Application Note

High-Performance Somatic Variant Analysis

Targeted next-generation sequencing (NGS) is a well-established and powerful tool for somatic oncology research. NGS pipelines for the analysis of somatic variants require efficient methods for enriched library preparation from challenging sample types, relevant, optimized enrichment panels and advanced bioinformatic tools.
Application Note

Analysis of Cancer Spheroids Through High-Throughput Screening Assays

Download this app note to discover how you can overcome challenges such as maintaining the shape and size of spheroids to reduce variability.
Application Note

Cell Viability Assays - Which One Is Best Suited for My Application?

Download this app note to discover a microplate reader that covers a broad range of cell viability assay readouts, provides high sensitivity and full flexibility and offers a fast and easy assay setup.
Application Note

Quantifying T Cell Response in 3D Tumor Spheroids Using Advanced Flow Cytometry Workflows

Discovery of novel immunotherapies that specifically target and enhance the T cell response against cancer is a rapidly expanding research area. Robust and relevant in vitro models for evaluation of these immunotherapies is essential throughout their development.
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