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Latest App Notes & Case Studies

Rapid Phosphoproteomics With DIA-PASEF content piece image
App Note / Case Study

Rapid Phosphoproteomics With DIA-PASEF

Data-independent acquisition (DIA) has been shown to increase the quantitative reproducibility and accuracy of MS-based phosphoproteomics. This app note explores the impact of dia-PASEF on the speed and sensitivity of phosphoproteomics.
Automated Parallel Capillary Electrophoresis for Purity Analysis of ssDNA and RNA Oligonucleotides content piece image
App Note / Case Study

Automated Parallel Capillary Electrophoresis for Purity Analysis of ssDNA and RNA Oligonucleotides

As oligonucleotides (oligos) are synthesized, small amounts of impurities can be introduced at each step, and different synthesis methods and purification efficiencies can impact the quality of the sample.
Ensuring Quality Control of IVT RNA Workflows content piece image
App Note / Case Study

Ensuring Quality Control of IVT RNA Workflows

From vaccines to gene therapies, RNA produced by in vitro transcription (IVT) has many therapeutic applications.
High Resolution Mapping of the Breast Cancer Tumor Microenvironment content piece image
App Note / Case Study

High Resolution Mapping of the Breast Cancer Tumor Microenvironment

Single cell and spatial technologies that profile gene expression across whole tissues are revolutionizing the resolution of molecular states in clinical tissue samples.
High-Throughput
App Note / Case Study

Novel High-Throughput Image Cytometry Method for T-Cell Immunophenotyping and Viability Readouts

The cell therapy manufacturing process requires the guidance of chemical manufacturing and controls for analytical method development focusing on the critical quality attributes (CQAs).
Effortlessly Analyze Pyruvate Kinase Inhibitors content piece image
App Note / Case Study

Effortlessly Analyze Pyruvate Kinase Inhibitors

Pyruvate kinase is an enzyme involved in energy-supplying glycolysis and ATP synthesis, thus is pivotal for the eucaryotic energy metabolism. In addition, overexpression of pyruvate kinase is believed to play a role in cancer.
Early Screening of Pancreatic Cancer Immunotherapy Target Candidates content piece image
App Note / Case Study

Early Screening of Pancreatic Cancer Immunotherapy Target Candidates

It has proven difficult to accurately identify the biological targets of cancer, which are necessary for the development of successful therapeutics including novel immunotherapies, such as those based on chimeric antigen receptor (CAR) T cells.
Contract Manufacturing for a Novel Metabolism-Based Liquid Biopsy content piece image
App Note / Case Study

Contract Manufacturing for a Novel Metabolism-Based Liquid Biopsy

When it comes to cancer, diagnosis often relies on tissue biopsy in conjunction with medical imaging. In addition to sometimes being inconclusive, tissue biopsies are associated with risks, high costs and inconvenience for patients, making them ill-suited for screening or tracking disease progression.
Development of a Targeted Plasma Quantitation Assay Using dia-PASEF content piece image
App Note / Case Study

Development of a Targeted Plasma Quantitation Assay Using dia-PASEF

In clinical proteomics research applications, blood plasma is the key sample of interest, but comprehensive proteome analysis can be challenging due to the large dynamic range of concentration.
Progress Towards Out-of-the-Box Sub-Cellular Imaging content piece image
App Note / Case Study

Progress Towards Out-of-the-Box Sub-Cellular Imaging

Single cell analysis in a spatially resolved context is the gateway to deciphering scientific questions in various application areas. Such analysis requires the highest available spatial precision combined with highly sensitive detection.
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