Latest App Notes & Case Studies

Targeted sequencing based on NGS offers new perspectives in drug selection for cancer patients. The accuracy of mutation analysis relies on the tumor content of the tissue samples.

Monoclonal antibody (mAb)–based therapeutics have been very successful in treating various diseases, including cancer. The manufacturing of these therapeutic antibodies is a complex operation with low levels of aggregates being a critical quality attribute of the final product, as this will impact the biological activity.

The composition of the cryopreservation medium can have a big impact on the recovery of viable cells after thawing. Learn how long-term cryopreservation with MACS® Freezing Solution can maintain the viability and stability of cell suspensions and tissue samples.

This application note demonstrates how reliable kinetics and affinity can be obtained from single measurement data, increasing sample throughput and saving sample material.

Adeno-associated virus (AAV) technology has become a crucial method for delivering gene therapy drugs and vaccines. The quantitation of viral capsids enables researchers to ensure that AAV preparations are of high quality and potency. However, challenges remain with the accurate quantitation and detection of multiple AAV serotypes.

Studying DNA methylation at correlated gene regions can provide researchers with insights into disease-associated epigenetic variation. Hence, cost-effective sequencing is essential for our advancement and understanding of epigenetic epidemiology.

Formalin-fixed, paraffin-embedded (FFPE) tissue is a valuable resource in the retrospective proteomic analysis of clinical and non-clinical samples. However, sample preparation techniques typically involve laborious, time-consuming and potentially hazardous xylene-based deparaffinization steps.

CAR-T cell therapy has emerged as one of the most promising novel treatments in the fight against cancer.

Metabolism is a key driver of CAR-T cell fitness and function. Hence, metabolic preconditioning methods can enhance the bioenergetic capacity of CAR-T cells in culture, supporting their persistence and antitumor activity

Download this app note to learn how you can select 20 individual CTCs in 10 minutes, this approach can be used for DNA, RNA or proteome analysis as well as how these target cells are selected and isolated in high purity from heterogenous backgrounds.