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Identification of a Tumor–Specific Gene Regulatory Network in Human B-Cell Lymphoma

Simultaneous readout of transcriptomic and epigenomic data from the same cell at single cell resolution allows for direct reconstruction of cell type–specific gene regulatory networks that does not rely on inference or assumptions to tie the two data types together. Multiomic analysis of paired RNA-seq and ATAC-seq data from a single cell enables direct linkage of differentially accessible DNA regions to proximal differentially expressed genes to identify putative regulatory targets.

Download this app note to discover how to:

  • Distinguish tumor versus normal cells in a heterogeneous sample
  • Reconstruct cell type–specific gene regulatory network
  • Confirm PAX5 as a critical regulator specific to tumor B cells