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Epigenetics and Drug Discovery
ArticleThis article aims to highlight the key types of epigenetic modification, summarize current and emerging drug discovery efforts to target epigenetic dysregulation and will discuss some of the benefits and challenges of epigenetic therapeutics.
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One-Way vs Two-Way ANOVA: Differences, Assumptions and Hypotheses
ArticleA key statistical test in research fields including biology, economics and psychology, Analysis of Variance (ANOVA) is very useful for analyzing datasets. It allows comparisons to be made between three or more groups of data. Here, we summarize the key differences between these two tests, including the assumptions and hypotheses that must be made about each type of test.
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Biosafety and the Agents of Doom
Article
To combat harmful pathogens it is vitally important that scientists have facilities available that enable them to work on them safely. These facilities should prevent the operator from becoming infected with the agent they are working with and prevent the organism from escaping the laboratory setting and potentially initiating new outbreaks of disease.
Wnt Signaling in Cancer
ArticleAberrant Wnt signaling has also been identified as a key mechanism in cancer biology. This article summarizes both the canonical (β-catenin dependent) and non-canonical (β-catenin independent) signaling pathways. It also highlights the role of Wnt signaling in numerous cancers and discusses novel approaches to targeting the pathway.
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The Glycome and Cancer
ArticleThe surfaces of cancer cells frequently express different types of glycoproteins, and because healthy cells don’t express these molecules (or do so at a much lower level), there has been significant interest in them as potential anticancer targets. Recent advances suggest we are about to see a resurgence in cancer glycomics.
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Cisplatin Efficacy: The Importance of Measuring Uptake in Cancer Cells
ArticleAlthough cisplatin is clinically proven to combat numerous human cancers – bladder, head and neck, lung, ovarian, testicular – resistance to treatment remains a key challenge, and cisplatin patients can often relapse. Having the ability to determine the cellular uptake of cisplatin is key to developing novel strategies to increase tumor cell sensitivity to cisplatin.
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Cell Potency: Totipotent vs Pluripotent vs Multipotent Stem Cells
ArticleHere we discuss the differences between totipotent, pluripotent, and multipotent stem cells.
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Henrietta Lacks: The Mother of Modern Medicine
ArticleA portrait of Henrietta Lacks has recently been unveiled at the Smithsonian’s National Portrait Gallery, to recognize her life and the vital contributions HeLa cells have made to science.
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How Mass Spectrometry Has Changed the Cancer Diagnostics Game
ArticleAlthough histopathology is still the gold standard for diagnosing cancer, molecular analysis using MS has gained traction in recent years for detecting tumors, monitoring progression, and even predicting treatment response.
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Exploiting the Tumor Microenvironment for Cancer Therapeutics
ArticleIt’s more than a century since Paget first proposed the ‘soil and seed’ hypothesis in cancer, providing evidence that the environment surrounding a tumor is as important as the tumor itself. Research in this area has gathered momentum and it’s now the focus of intense research efforts.
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