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Latest Articles

Single-Cell DNA Sequencing Weaves a Way Towards Personalized Cancer Treatment
Article

High-throughput single-cell analysis has been regularly acclaimed as a transformative technology for sequencing and a huge step towards the goal of personalized medicine. Will Tapestri, a sequencing platform developed by Mission Bio, be the game-changer in DNA analysis we have been waiting for?

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One-Pot Reactions: Synthesizing Natural Product Analogs for Drug Discovery
Article

Scientists have discovered powerful new reactions for the synthesis of nature-inspired privileged structures – one-pot, modular, elegantly designed chemical reactions that could minimize the gap between the chemical and biological space. Their study findings could be a turning point for the discovery of unmet diseases.

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Emerging Classes of Next-generation Biotherapeutics
Article

We are entering uncharted territory in biopharmaceutical development. Emerging new classes of treatments are harnessing the natural power of viruses and cells and engineering them to fight human diseases. As our arsenal of conventional therapies begins to fail, a new army of biotherapeutics is on the horizon. Here, we look at two new classes of treatments leading the charge.

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High-Throughput LC-MS for Early Drug Screening and Biomarker Detection
Article

In this article, we explore two novel high-throughput analytical methods based on liquid chromatography-mass spectrometry (LC-MS) analysis that can augment early drug screening and biomarker detection in the clinic.

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Medical Devices: How to Master New Clinical Evaluation Report Criteria
Article

To achieve regulatory compliance and authorization for sale in Europe, every medical device must be supported by a Clinical Evaluation Report which documents the entire clinical evaluation process. Read on for recommendations on how manufacturers can keep up with the changing regulation landscape.

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Exploiting Epigenetics in Cancer Treatment
Article

Changes to the complex of DNA and the proteins that form chromatin are important drivers in many cancers. We explore the challenges and progress in the development of new therapies targeting epigenetic regulators.

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Through the Looking Glass of Single Cell Proteomics
Article

To pick apart the differences between individual cells in complex multicellular organisms, we need to look at cells one-by-one. This article takes a look at how several scientists in North America are using single cell proteomics (SCP) technologies to discern disease pathogenesis and enhance directed stem-cell differentiation.

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Untargeted Profiling of Metabolites: In Search of Cancer Biomarkers and Antibiotics
Article

When you are examining a predetermined set of metabolites (in other words, when you know what you are looking for), targeted approaches can be adopted. But when a comprehensive profile of all the metabolites in a sample, known and unknown, is required, untargeted technologies are the way to go. Here, we look at how how untargeted metabolomics is helping science discover new biomarkers for cancer and natural antibiotic sources.

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Chemical Snapshots and Molecular Maps with Mass Spec Imaging
Article

Mass spectrometry imaging (MSI) is a powerful tool increasingly being used in many fields including cancer research, biomarker discovery and drug development. This article explains why MSI is the technique of choice in many labs, discusses its use in research, and covers how some inherent challenges are being addressed.

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Cancers of the Lung and the Rise of Artificial Intelligence
Article

Artificial intelligence (AI) has begun to transform the world of healthcare and researchers across the globe are now dedicated to discovering its potential. This technology has particularly struck a chord with cancer research surrounding early detection, a long-standing concern for the cancer community.

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