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Navigating Targeted Protein Degraders: Advanced Analytical Tools

Navigating Targeted Protein Degraders
Credit: iStock

Over 85% of the human proteome lacks clear binding sites that can be targeted by standard pharmaceuticals. This renders many protein targets “undruggable”.

Targeted protein degradation (TPD) tackles this issue by directly regulating cellular machinery, enabling the destruction of specific, otherwise undruggable proteins. However, conventional TPD therapeutic discovery pipelines can be time-consuming, complex, and miss key off-target effects.  

This eBook explores how recent advances in trapped ion mobility spectrometry (TIMS) have revolutionized TPD for a faster, more accurate development processes. 

Download this eBook to discover:

  • How proteomic approaches can help create more effective TPD therapeutics
  • The advantages of TIMS over conventional mass spectrometry
  • How to reduce drug attrition with early identification of off-target effects
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