Understanding Tumor Microenvironment Signaling Pathways
Understanding Tumor Microenvironment Signaling Pathways and Attempts To Target Components in Solid Cancer Therapy
The tumor microenvironment (TME) is comprised of the tumor, extracellular matrix and various non-transformed cells including fibroblasts, immune infiltrates and vascular vessels. TME plays a key role in tumor initiation, progression, invasion, metastasis and resistance. Understanding TME requires close examination of signaling pathways responsible for its characteristics.
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- Receptor tyrosine kinase signaling
- Cytokine receptors
- Ancient signaling