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Three-dimensional (3D) cell models are more biologically relevant than two-dimensional cell cultures as they more closely represent the tissue microenvironments, cell-to-cell interactions, and biological processes that occur in vivo. But how can you accurately and consistently generate more predictive data, while maintaining high-throughput and reducing cost?

A range of microscope objectives are available and the optimal choice for a given sample and application will depend on several technical factors. Prices can vary from a few hundred dollars to several thousand and in many cases is a real consideration as well. By an understanding of the factors that influence image quality (contrast, signal-to-noise, resolution, etc.), as well as the terms that describe objective classes and types, well-informed decisions can be made and data appropriate for the purpose of the experiment more easily generated.

New, Bright, Fluorescent Nanoparticles Developed for Flow Cytometry. Bio-Rad has now launched ten StarBright Dyes, including StarBright Blue 700, eight StarBright Violet Dyes, and the latest in the range StarBright UltraViolet 400, with many more due to be launched over the coming year.

Eliminate the challenges that come with manual ELISAs. Meet Ella™ — your next generation automated ELISA instrument from Bio-Techne. In just 90 minutes you get highly reproducible validated assay data with no manual steps.

Drug product glycosylation is a critical quality attribute (CQA) due to its potential impact on pharmacokinetics properties and stability of the product. The ability to view and choose from desired titer and glycosylation profiles at the same time provides more in-depth knowledge that facilitates more informed decisions.

The utility and efficiency of the Octet® platform at characterizing covalent immune recruiter molecule function and their efficacy as modulators of protein proximity was demonstrated. Efficient in vitro validation further enables the potential acceleration of CIR translation to in vivo model validation and the clinic as a new class of synthetic tumor immunotherapeutic.

Optimized for fast 3D multi-sample volume imaging of delicate live specimen in their native 3D environment, the TruLive3D Imager is especially suited for multi-position imaging of small embryos (e.g., mouse), 3D spheroids, organoids, oocytes and more, enabling time-lapse, high-throughput imaging experiments.

Mass cytometry, with detection by TOF, has been a transformative single-cell technology in immunology, immunophenotyping, oncology and infectious disease studies for a decade. It is in use in over 150 clinical trials worldwide and is cited in more than 1,200 peer-reviewed publications.