Inflammatory responses are characterized by the release of endogenous DAMPs, also known as alarmins. During non-apoptotic programmed or regulated cell death, such as pyroptosis and necroptosis, HMGB1 is released along with other pro-inflammatory molecules.
Due to the significance of HMGB1 in these processes, it is important to be able to accurately and reliably monitor its release.
In this application note, discover more about the HTRF HMGB1 kit for monitoring HMBG1, including:
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