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New Subtype of Prostate Cancer
New Subtype of Prostate Cancer
News   Jun 18, 2018

Researchers led by the University of Michigan Rogel Cancer Center have identified a new subtype of prostate cancer that occurs in about 7 percent of patients with advanced disease.

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New Ovarian Cancer Target
New Ovarian Cancer Target
News   Jun 14, 2018

Researchers have found a prescription drug, Calcitriol, approved by the Food and Drug Administration for the treatment of calcium deficiency and kidney diseases, may increase the likelihood of surviving ovarian cancer. This new study opens a potential avenue for treating ovarian cancer. Since Calcitriol is an FDA-approved drug, no additional research is needed before the drug can advance to human clinical trials for ovarian cancer.

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Cryo-EM Reveals Interaction Between Major Drug Targets
Cryo-EM Reveals Interaction Between Major Drug Targets
News   Jun 14, 2018

For the first time, scientists have visualized the interaction between two critical components of the body's vast cellular communication network, a discovery that could lead to more effective medications with fewer side effects for conditions ranging from migraine to cancer.

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Genetic Discovery Helps Determine the Difference Between Aggressive & Benign Bone Tumors
Genetic Discovery Helps Determine the Difference Between Aggressive & Benign Bone Tumors
News   Jun 13, 2018

The first genetic marker for the bone tumor, osteoblastoma, has been discovered. Whole-genome and transcriptome sequencing of human bone tumors revealed that a genetic change that affects the transcription factor, FOS, is a hallmark mutation of osteoblastoma. The results will help clinicians correctly distinguish benign osteoblastoma tumors from aggressive osteosarcoma tumors and direct the correct treatment.

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63 New Genetic Variations in DNA Increase Prostate Cancer Risk
63 New Genetic Variations in DNA Increase Prostate Cancer Risk
News   Jun 12, 2018

A major new study of more than 140,000 men has identified 63 new genetic variations in the DNA code that increase the risk of prostate cancer.

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Epigenetic Drug Against Mantle Cell Lymphoma
Epigenetic Drug Against Mantle Cell Lymphoma
News   Jun 12, 2018

A new study presents an epigenetic drug capable of slowing down cell growth in Mantle Cell Lymphoma (MCL), a type of cancer characterized by its aggressive behavior, its delayed diagnosis with affectation of different organs and its origin from the lymphocytes B.

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Study Identifies Cellular ‘Death Code’
Study Identifies Cellular ‘Death Code’
News   Jun 11, 2018

Dying cells generally have two options: go quietly, or go out with a bang. The latter, while more conspicuous, is also mechanistically more mysterious. Now, scientists have pinpointed what they believe is the molecular "code" that unleashes this more violent variety of cell death.

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Breaking Through a Tumor’s Defenses
Breaking Through a Tumor’s Defenses
News   Jun 08, 2018

Researchers have shown that some tumors use not one but two levels of protection against the immune system. Knocking out one level boosted the protective effects of the second and vice versa. A two-pronged approach targeting both cell types simultaneously may offer a promising route for the development of new cancer immunotherapies.

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Stem-Cell Niche for 10 Billion Colon Cells a Day
Stem-Cell Niche for 10 Billion Colon Cells a Day
News   Jun 08, 2018

Researchers at the University of Zurich have discovered the identity of the stem-cell niche of the colon. The niche comprises special cells that activate the stem cells of the adjacent intestinal epithelium and are responsible for its continuous renewal.

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Telomerase: Highest Level of Detail Ever Seen
Telomerase: Highest Level of Detail Ever Seen
News   Jun 07, 2018

Researchers report the deepest scientific understanding yet of this once-mysterious enzyme, whose catalytic core -- where most of its activity occurs -- can now be seen in near atomic resolution. Telomerase is especially active in cancer cells, which enables cancer to grow and spread.

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