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Virus-Mimicking Drug Improves Immune System’s Ability To Target Cancer Cells
News   Oct 15, 2020

Researchers have found that a drug that activates the body's natural defenses by behaving like a virus may also make certain melanoma tumors visible to the immune system, enabling the cancer cells to be better targeted by immunotherapy.

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How Cells Can Recover Their Longevity After Genome Damage
News   Oct 14, 2020

A research team from Cologne has discovered that a change in the DNA structure – more precisely in the chromatin – plays a decisive role in the recovery phase after DNA damage. The key is a double occupation by two methyl groups on the DNA packaging protein histone H3 (H3K4me2).

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First Structural Model of BAF Complex Sheds Light on Cancer
News   Oct 14, 2020

Scientists have created an unprecedented 3-dimensional structural model of a key molecular “machine” known as the BAF complex, which modifies DNA architecture and is frequently mutated in cancer and some other diseases.

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Determining if Tumor Gene Testing Can Select Efficacious Precision Cancer Treatments
News   Oct 14, 2020

NCI-MATCH precision medicine trial makes major contributions to the use of tumor gene testing to select treatment for patients. Newly published data has broad relevance in medicine, providing a roadmap for future precision medicine trials.

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Studying Mole Growth Could Help To Develop Drugs for Skin Cancer
News   Oct 14, 2020

Moles stop growing when they reach a specific size due to normal interactions between cells, despite having cancer-associated gene mutations. This finding could help to develop novel ways to prevent skin cancer growth that can take advantage of normal cell growth mechanisms.

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Novel Therapeutic Vaccine Against Leukemia Developed
News   Oct 13, 2020

Researchers from the Institute of Process Engineering (IPE) of Chinese Academy of Sciences and Zhujiang Hospital of Southern Medical University have developed a new type of precise therapeutic vaccine against leukemia. It utilizes self-healing polylactic acid microcapsules for co-encapsulating a new epitope peptide and PD-1 antibody.

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A Novel Therapeutic Approach Against Epstein-Barr Virus-Associated Tumors
News   Oct 13, 2020

A research team from The University of Hong Kong (HKUMed) has discovered that exosomes derived from Vδ2-T cells can effectively control Epstein-Barr virus-associated tumors and induce T-cell antitumor immunity.

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Neoantigens Could Be Key to Unlocking a New Generation of Immunotherapies
News   Oct 12, 2020

Scientists have discovered parameters to better predict which neoantigens can stimulate a cancer-killing effect.

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Experimental Glioblastoma Drug Enhances Survival in Mouse Model
News   Oct 12, 2020

Houston Methodist researchers found that mice harboring human glioblastoma tumors in their brains had greatly enhanced survival and weight gain when given a newly developed prodrug. Human glioma cells were removed from patients during surgical excision and isolated within 10 minutes after removal. The glioblastoma cells were injected into the brains of 48 female mice for a 300-day study. The prodrug was well tolerated, and, when given on its own, extended survival by more than a factor of three.

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Urine-Based Liquid Biopsy Test Outperforms Urine Cytology in Detecting Bladder Cancer
News   Oct 12, 2020

Analysis of DNA copy number variants in the cells exfoliated in urine showed better sensitivity and similar specificity in detecting urothelial carcinoma compared with urine cytology.

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