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Invasive Weed Could Help To Treat Cancer and Diabetes
An international team of scientists has discovered that extracts of a weedy grass called Andropogon virginicus appear to be effective against several human diseases, including diabetes and cancer.
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Immune Cells in Cerebrospinal Fluid Predict Response to Immunotherapy
The analysis of immune cells infiltrating cerebrospinal fluid enables the characterization of the tumor microenvironment in brain metastases. Findings confirm that these cells could act as novel and non-invasive biomarkers to predict patient responsiveness to immune-based therapies.
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Novel Inhibitor Shown To Combat Drug-Resistant Tumor Cells
A team of researchers from Martin Luther University Halle-Wittenberg and the University of Greifswald has developed a new inhibitor of multi-drug resistant protein 4 (MRP4). When the inhibitor was tested on drug-resistant cancer cell lines, the cancer cells began to respond to chemotherapy.
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Probing the Proteomic Landscape of Cancer To Discover Drug Targets
Researchers have shown that analysis of the proteomics, or all the protein data, from aggressive human cancers is a valuable strategy to identify potential novel therapeutic targets.
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Boosting Radiotherapy Response With Targeted Immunotherapy
A new study discovered that profiling the immune landscape of cancers before therapy could help to identify patients who are likely to respond to radiotherapy straight away, and others who might benefit from priming of their tumor with immunotherapy.
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Retracing the Lineage of Cancer Cells
Researchers have reconstructed the lineage history of cancer cells in two individuals with a rare blood cancer by calculating when the genetic mutation that gave rise to the disease first appeared. The findings present insights that could inform new approaches for early detection, prevention, or intervention.
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Mutant Protein Clusters Drive Cancer-Causing Aggregates
A mutation that replaces a single amino acid in a potent tumor-suppressing protein turns it from saint to sinister. A new study demonstrates why this alteration is more damaging than previously thought.
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Using Viruses To Train the Immune System To Tackle Tumors
A research group has developed a strategy that is being tested in clinical studies for therapeutic cancer vaccines. Using two different viruses as vehicles, they administered specific tumor components in mice with cancer in order to stimulate their immune system to attack the tumor.
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Drug Designed To Treat Cancers Associated With Epstein–Barr Virus
Epstein-Barr virus (EBV) has infected more than 90% of the human population worldwide. EBV is known to play a key role in several cancers such as nasopharyngeal carcinoma. A research team has developed a novel drug that could become a next-generation treatment for cancers associated with EBV.
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How Cells Build "Mini-Muscles" Underneath Their Nucleus
Defects in the assembly of stress fibers in cells lead to multiple disorders in humans. Researchers have discovered how myosin, the motor protein responsible for the contraction of skeletal muscles, functions in non-muscle cells to build stress fibers at the inner face of the cell membrane.
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