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Researchers from QIMR Berghofer Medical Research Institute have developed a prototype test that can help identify if patients with deadly metastasised melanoma are likely to benefit from immunotherapy.

Scientists report that they have discovered a potential new target for immunotherapy of malignant brain tumors. By blocking a specific signaling pathway in an animal model, the team was able to stimulate T-cell killing of cancer cells in the brain.

A liquid biopsy examining blood or urine can help gauge the effectiveness of therapy for colorectal cancer that has just begun to spread. Such a biopsy can detect lingering disease and could assist in deciding whether a patient requires further treatment.

p53 is a natural anticancer protein, sometimes called “guardian of the genome” due to its ability to repair DNA damage or destroy cancer cells. A study exploring the interaction between p53 and the green tea compound epigallocatechin gallate now points to a new therapeutic target.

A key enzyme, PRMT5, controls a large network of proteins important in cell division and growth. Inhibition of this enzyme paves the way for a new class of drugs that could stop glioblastoma, a deadly brain cancer, from growing.

Using mouse models, cancer researchers have identified mechanisms by which malignant tumor cells extend their toxicity to distinct cell types and in turn help them to spread.

The antibody–drug conjugate (ADC) enfortumab vedotin (PADCEV®) has been shown to increase the survival of patients with urothelial carcinoma in a recent study. Results from the randomized open-label Phase 3 trial were published in the New England Journal of Medicine.

One in twenty high-risk cancer patients face the possibility of developing heart failure from certain cancer therapies. Results of a clinical trial point to the benefit of using a more sensitive test to detect heart function issues early, so cancer patients don't have to fight heart failure too.

An early clinical trial has shown that a simple injection of a common antiseptic could boost the effectiveness of radiotherapy for breast cancer and other cancers. Scientists found that a solution of hydrogen peroxide, an antiseptic that cleans cuts and scrapes, can also make cancer cells more sensitive to radiotherapy.

Melatonin administration proved to be an independent prognostic factor and reduced the risk of death of prostate cancer patients in a retrospective study of 955 patients.