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Blood-Based Biomarkers Could Improve Detection of Breast Cancer
Breast cancer, even at its initial stages, could be detected earlier and more accurately than current techniques using blood samples and a unique proteomics-based technology, according to findings of a study led by the Translational Genomics Research Institute.
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How Do Blood Stem Cells Maintain Their Ability To Self-Renew?
A characteristic feature of all stem cells is their ability to self-renew. But how is this potential maintained throughout life?
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Antiviral Enzymes Convert Pre-Leukemia Stem Cells Into Leukemia
In response to inflammation, two enzymes called APOBEC3C and ADAR1 work together to trigger the transformation of pre-cancer stem cells to cancer stem cells in leukemia.
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Preventing Chemotherapy From Damaging the Heart
Researchers have discovered that the chemotherapy drug doxorubicin is able to enter heart cells by hitchhiking on a specific type of protein that functions as a transporter to move drugs from the blood into heart cells. By introducing another anti-cancer drug in advance of the chemotherapy, the team was able to block the transporter protein.
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A Promising Way To Find New Anticancer Drugs
Enzymes known as histone deacetylases are targets for a handful of anticancer drugs due to their ability to affect gene expression. Now, researchers have developed a new method to investigate how these enzymes work on a molecular level. This approach could help to identify new anticancer drug candidates quickly.
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New Technique Enables Continuous Monitoring of Proteins
Researchers have developed an antibody as a biosensor, to continuously monitor rapid changes in the concentration of EGFR, a protein present on cancer cells and in body fluids.
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Scientists Use Novel Ink To 3D-Print Bone-Mimicking Structures
Scientists from UNSW Sydney have developed a ceramic-based ink that may allow surgeons in the future to 3D-print bone parts complete with living cells that could be used to repair damaged bone tissue.
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Team Investigates Potential Drug Therapy Combination for Lung Cancer
Researchers report that in non-small-cell lung carcinoma, secondary mutations occurring with another gene alteration known as ALK make the efficacy of alectinib, an otherwise commonly used drug for treating lung cancer, become unfavorable. Combining alectinib with another drug could help to overcome these effects.
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COVID-19 Pandemic Causes Dramatic Changes to the Delivery of Radiotherapy Treatments
New research, led by the University of Leeds, with Public Health England and the Royal College of Radiologists, reveals dramatic changes in the delivery of radiotherapy treatments for cancer during the first wave of the coronavirus pandemic in England.
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New Maintenance Treatment Prolongs the Lives of Patients With Acute Myeloid Leukemia
Patients with acute myeloid leukemia (AML), that have gone into remission following initial chemotherapy remain in remission longer and have improved overall survival when they are given the cancer drug azacytidine, according to a randomized, international Phase 3 trial.
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