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Some Cancer Cells Exploit Neuronal Signaling To Metastasize
Rockefeller scientists found that breast and lung tumors can utilize a signaling pathway used by neurons to metastasize. These cancer cells enlist nearby blood vessels to gain access to the nerve signal, enabling their escape from the primary tumor and into the bloodstream.
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Call for Entries: Eppendorf Award 2021
Young researchers with an advanced degree can apply for the highly prestigious Eppendorf Award for Young European Investigators that acknowledges outstanding contributions to biomedical research in Europe .
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Understanding How Cisplatin Chemotherapy Causes Neuronal Damage
Researchers have shown that Cisplatin induces senescence of peripheral neurons through overexpression of the p21 protein, which would explain the neuropathy associated with this treatment.
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Novel Drug Disarms Cancer-Causing Protein Aurora
Aurora-A kinase is a protein that causes extensive damage to cells of the body and is known to trigger the development of leukemias and many pediatric cancers, such as neuroblastoma. Researchers at the universities of Würzburg and Frankfurt have now developed a drug that can disarm Aurora.
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Killing Cancer Cells by Blocking Access to the Nucleus
Scientists have demonstrated that by blocking the construction of nuclear pore complexes it was possible to shrink aggressive tumors in mice whilst leaving normal cells unaffected.
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New Cancer Drug Targeting DNA Repair Shows Promise in Early-Stage Trial
A new precision drug which stops cancer from repairing its DNA has shown promise in an early-stage clinical trial – highlighting the potential of a new class of drugs known as ATR inhibitors.
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Exposing Cancer's Vulnerabilities Using Specialized Microscopy
Scientists seek insight into what makes its cells tick. Caltech researchers have shown that a framework they developed, using a specialized type of microscopy, enables them to probe the metabolic processes inside cancer cells.
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University of New Hampshire Awarded $1.8 M To Explore Drug Interactions and Targeted Drug Development
The University of New Hampshire is set to receive $1.8 million from the National Institutes of Health. This will be used to further the university's research to better understand drug interactions at the cellular level and help develop new targeted drugs to treat disorders including diabetes and cancer.
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Circular RNA Molecule ciRS-7 Not Found in Cancer Cells After All
New research from Aarhus University shows that a circular RNA molecule, which has been designated as carcinogenic, is actually not found in the cancer cells. Researchers suggest that the molecule contributes to the development of cancer through what is known as the microenvironment.
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182 Genes Identified That Regulate Interactions Between Cancer Cells and T Cells
Toronto scientists have mapped the genes allowing cancer cells to avoid getting killed by the immune system that paves the way for the development of immunotherapies that would be effective for larger patient populations and across different tumour types.
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