News

Tetrahydrocannabinol (THC) may be able to prevent the development of colon cancers, say researchers from the University of South Carolina.

New research has uncovered the presence of CD19 -- a B cell molecule targeted by chimeric antigen receptor (CAR) T cell immunotherapy to treat leukemia, lymphoma, and multiple myeloma -- in brain cells that protect the blood brain barrier (BBB).

Researchers report novel findings concerning the therapeutic mechanisms of pomalidomide. They showed that pomalidomide causes the breakdown of a protein called ARID2. ARID2 promotes the "expression" of genes that are critical for the growth of multiple myeloma cells, so breaking down ARID2 is harmful to the cancer cells and beneficial to patients.

In a Phase I clinical trial for patients with advanced solid cancers marked by KRAS G12C mutations, the KRASG12C inhibitor sotorasib (AMG 510) resulted in manageable toxicities and durable clinical benefit.

Adding abemaciclib to hormonal therapy reduces the risk of cancer recurrence by 25% in patients with high-risk early hormone receptor-positive (HR+) human epidermal growth factor receptor 2 negative (HER2-) breast cancer, according to trial results.

Results from the PROfound trial have showed that olaparib – a drug called a PARP inhibitor – can be used successfully to treat prostate cancers with a "weakness" in their ability to repair damaged DNA.

Scientists have created new mathematical tools that allow scientists to search the vast collection of DNA snippets and uncover whether there are either missing pieces or duplicates. These algorithms, dubbed HATCHet and CHISEL, could help to improve diagnosis and treatment.

A new study has led to a better understanding of how key components of the body’s immune system find intruding or damaged cells, which could lead to novel therapeutic approaches against viral infection and cancer.

Researchers have discovered new markers, known as HLA-associated peptides, that are uniquely present on melanoma tumors. This finding could pave the way for therapeutic vaccines to be developed against melanoma.

A team of researchers has published a new study on how the composition of ovarian cancer tumors changes during chemotherapy and contributes to therapeutic response.