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Team Identifies Key Molecule Responsible for Poor Prognosis of Breast Cancer
A research team has shown that Interleukin-34 is a prognostic marker and drug target for Triple Negative Breast Cancer.
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Treating Cancer With Rejection-Resistant “Off-the-Shelf” T Cells
Researchers are developing ready-to-use, off-the-shelf therapeutic T cells. The cells, which are manufactured from healthy donors, are expanded and well-characterized and have shown to be effective at killing cancer cells.
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Activating Immune-Boosting Protein “STING” as a Cancer Treatment Strategy
Scientists have discovered a molecule that can activate a natural immune-boosting protein called STING (STimulator of INterferon Genes). The STING protein is known for its strong antitumor properties.
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Blocking Copper Uptake in Cancer Cells May Be Key To Boosting Immune Response
Researchers have discovered that removing copper from the blood can destroy some of the deadliest cancers that are resistant to immunotherapy using models of the disease.
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Link Between Gut Microbiome and Cancer Treatment Outcomes
Researchers have found that greater gut microbial diversity in patients with metastatic kidney cancer is linked to a better treatment outcome, for patients on FDA-approved immunotherapy regimens.
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New Breast Cancer Database Could Help To Develop Personalized Treatments
A new database of 40 breast cancer cell lines aims to help researchers deepen their understanding of these cell lines and speed up the development of new gene-targeted therapies.
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Ketone-Supressing Drug Combats Rare Brain Cancer in Mice
In a study funded by the National Institutes of Health, researchers showed that experimental drugs designed to lower the body’s natural production of alpha-ketoglutarate extended the lives of mice with brain tumors by slowing the growth of the cancer cells.
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Study Reveals Dynamics of Nanoprodrugs Inside Cancer Cells
Alternative carrier-free systems, known as nanoprodrugs (NPD), show immense promise for cancer treatment. Now, researchers have carried out a study on the dynamics of SN-38 NPDs inside cancer cells, looking specifically at their internalization rate, intracellular localization and degradation, as well as their therapeutic efficiency.
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Why Younger Female Patients Have Low Response Rates to Some Cancer Immunotherapies
A new study suggests that since the typically robust immune systems of young, female patients are better at getting rid of cancer cells, the cells left behind are not as readily visible to the immune system to begin with, meaning some types of immunotherapy are ineffective.
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Analysis of 28,000 Tumors Uncovers 568 Cancer Driving Genes
Analysis of the genomes of 28,000 tumors from 66 types of cancer has led to the identification of 568 cancer driver genes.
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