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Cancer: Central Role of Cell “Skeleton” Revealed
All cells possess a cytoskeleton which allows them to move and maintain their shape. Scientists recently showed that a part of this cytoskeleton called branched actin is also essential to cell proliferation: this actin transmits information to cells on whether they should proliferate. If the necessary conditions are not met, these actin fibres are not synthesized, and the cell does not divide – except in the case of cancerous cells, which can override this control mechanism.
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Dogs Can Accurately Sniff Out Cancer in Blood
A new study has shown that dogs can use their highly evolved sense of smell to pick out blood samples from people with cancer with almost 97 percent accuracy. The results could lead to new cancer-screening approaches that are inexpensive and accurate without being invasive.
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Spying on Cells' Eating Habits Could Aid Cancer Diagnosis
Scientists have developed a new imaging technology to visualize what cells eat, which could aid the diagnosis and treatment of diseases such as cancer.
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Famous p53 Gene Also Protects Against Birth Defects
New research has revealed how the famous tumour suppressor gene p53 is surprisingly critical for development of the neural tube in female embryos.
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Mapping Tumor Immune Cell Populations Points to Immunotherapy Targets
Tumors are a complex mixture of many different cell types, including immune cells known collectively as tumor-infiltrating myeloid cells. These cells represent alternative targets for immunotherapy, but their role in tumors is still poorly understood. To shed light on this under-examined family of immune cells, researchers used single-cell sequencing to map the landscape of myeloid cells in tumors from patients with lung cancer.
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Cancer-killing Combination Therapies Revealed Using Drug Screening Tool
Scientists have designed a large-scale screen that efficiently identifies drugs that are potent cancer-killers when combined, but only weakly effective when used alone. Using this technique, the researchers eradicated a devastating blood cancer and certain solid tumor cells by jointly administering drugs that are only partially effective when used as single-agent therapies.
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Vaccine Progress for Virus Behind “The Kissing Disease”
Progress has been made towards developing a vaccine for the Epstein-Barr virus, a herpesvirus that causes infectious mononucleosis and is associated with certain cancers.
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Gene Linked to Common Form of Liver Cancer Opens New Treatment Avenues
Researchers provide the first summary of the experimental evidence supporting the AKR1B10 enzyme as a promising therapeutic target for the most common form of liver cancer, based on a review of more than 50 studies published since this gene was first identified and characterized in 1998.
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Turning Tumors Into Cancer Vaccine Factories
A novel approach to cancer immunotherapy involves injecting immune stimulants directly into a tumor to teach the immune system to destroy it and other tumor cells throughout the body.
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Global Microbial Signatures for Colorectal Cancer Established
Patients with colorectal cancer have the same consistent changes in the gut bacteria across continents, cultures, and diets.
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