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The structure of an antibody, with different areas shown in red, orange and yellow.
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Improved Understanding of Immune Complement System Could Help Therapeutic Developments

New research has illustrated that activating the immune complement system can enhance cancer immunotherapies.
An African elephant.
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Hot Testicle Hypothesis May Explain Why Elephants Evolved Anti-Cancer Genes

University of Oxford Professor Fritz Vollrath puts forth his “hot testicle hypothesis”. Vollrath suggests that elephants may carry more copies of p53 encoding genes due to an evolutionary mechanism that functions to protect sperm against harsh temperatures, but serendipitously offers cancer protection.
A computer-generated illustration of some cancer cells.
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Follow the Leader: Cancer Invasion Mechanism Identified

Researchers have shed light on a potential therapeutic target to halt the invasion and spread of cancer cells, also providing a prognostic marker to help treatment selection.
A group of men sitting and talking.
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Risk Factors for Early Onset Colorectal Cancer in Males Identified

A new study identifies seven risk factors that convey higher-than-average risk for early-onset colorectal cancer in males.
Half of the screen shows blue cells with a few small pink dots, the other half shows blue cells with lots of pink dots.
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Researchers Reveal How Cells Rewrite Their Fate

Researchers have revealed how cells accelerate changes to their identity, a process known as cell fate conversion.
A patient model wearing a short face mask is positioned in a computed tomography (CT) scanner to obtain images of a tumor before radiation therapy.
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AI Model More Accurate Than MRI at Predicting Tumor Margins

Scientists at UCLA developed an AI model that helps determine how extensive cancer is within the prostate gland.
Strands of DNA overlaid with a transparent image of red liquid.
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DNA Changes Identified That Lead to Aggressive Colon Cancer

Researchers have identified DNA changes unique to aggressive liver metastasis not present in primary tumors or in the normal colon.
Kidney model
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New Model Sheds Light on Kidney Cancer Metastasis

Researchers have engineered a new model of aggressive renal cell carcinoma that highlights molecular targets and genomic events that trigger chromosomal instability and drive metastatic progression.
Representation of human cells.
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Immune Cell Marker and Regulator of Anti-Tumor Immunity Uncovered

Researchers at Brigham and Women’s Hospital investigated the role of B cells in anti-tumor immunity and identified a subset of cells that may play a critical role.
Cancer cells.
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Potential Biomarkers of Positive Response to Immunotherapy Uncovered

Scientists at the UCLA Jonsson Comprehensive Cancer Center have identified potential new biomarkers that could indicate how someone diagnosed with metastatic melanoma will respond to immunotherapy treatment.
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