We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Advertisement
Blood Cancer Study Posts Outstanding Results
News

Blood Cancer Study Posts Outstanding Results

Blood Cancer Study Posts Outstanding Results
News

Blood Cancer Study Posts Outstanding Results

Read time:
 

Want a FREE PDF version of This News Story?

Complete the form below and we will email you a PDF version of "Blood Cancer Study Posts Outstanding Results"

First Name*
Last Name*
Email Address*
Country*
Company Type*
Job Function*
Would you like to receive further email communication from Technology Networks?

Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our Privacy Policy

Scientists have described new results of a blood cancer study as ‘outstanding’ in tackling previously untreatable forms of chronic lymphocytic leukaemia (CLL).


The advance led by a team from our University and University Hospitals of Leicester NHS Trust, within the Hope Clinical Trials Facility, focused on treating patients with CLL.


It follows on from a world-first clinical trial of a new drug to treat particular blood cancers. Results of that international clinical trial, led by Dr Harriet Walter and Professor Martin Dyer were published in the journal Blood in November 2015 and looked at the efficacy of a new inhibitor, ONO/GS-4059, in the treatment of CLL and Non-Hodgkin Lymphoma patients, refractory or resistant to current chemotherapies.


ONO/GS-4059 targets BTK, a protein essential for the survival and proliferation of the tumour cells.


The study opened in January 2012 and 90 patients were enrolled in different centres in the UK and in France, with 28 coming from Leicester. Patients with CLL showed the best response and most of them were still on the study after 3 years, and remarkably without notable toxicities.


In the new paper, the researchers are reporting for the long-term follow-up results. Their work, published in the journal Blood, was funded by the Ernest and Helen Scott Haematological Research Institute, ONO Pharmaceuticals, Gilead Pharmaceuticals and the Cancer Research UK  Leicester Experimental Cancer Medicine Centre.  Local charity Hope Against Cancer fund the Clinical Trials Facility based at the Leicester Royal Infirmary.


Professor Martin Dyer is Professor of Haemato-Oncology in the Department of Cancer Studies at the University of Leicester and Honorary Consultant Physician in the Department of Haematology at Leicester Royal Infirmary. He said: “This current paper describes the long term follow up and shows that in patients with CLL the remissions are durable and associated with no new toxicities.  Furthermore, in collaboration with Sistemas Genomicos, a company in Valencia, we have shown that mutations associated with aggressive disease respond well to treatment with ONO/GS-4059.


“Our long term follow up shows maintained efficacy without toxicity. This study is the first report of long term follow-up of a selective BTK inhibitor – and it is excellent news for patients."


This article has been republished from materials provided by University of Leicester. Note: material may have been edited for length and content. For further information, please contact the cited source.


Reference


Walter, H. S., Jayne, S., Rule, S. A., Cartron, G., Morschhauser, F., Macip, S., ... & Shah, N. (2017). Long-term follow-up of patients with CLL treated with the selective Bruton's tyrosine kinase inhibitor ONO/GS-4059. Blood.

Advertisement