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CRISPR Enhances Cancer Immunotherapy Helping Protect T-Cells Against Friendly Fire

News   Mar 07, 2018 | Original story from Washington University School of Medicine in St. Louis

 
CRISPR Enhances Cancer Immunotherapy Helping Protect T-Cells Against Friendly Fire

Scientists at Washington University School of Medicine in St. Louis now have used the gene-editing technology CRISPR to engineer human T cells that can attack human T cell cancers. They also engineered the T cells to eliminate a potentially dangerous side effect called graft-versus-host disease, where the therapeutic T cells that kill the cancer also attack the patient's organs. John DiPersio, MD, PhD, (right) leads a team developing an "off-the-shelf" CAR-T immunotherapy for hard-to-treat T cell cancers. A new study evaluates the approach in mice with human T cell acute lymphoblastic leukemia. Shown is DiPersio working with co-author Armin Ghobadi, MD, in the lab. Credit: Huy Mach

 
 
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