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Differences Between Two Cancer-promoting Enzymes Discovered

News   Mar 28, 2019 | Original story from the University of Würzburg

 
Differences Between Two Cancer-promoting Enzymes Discovered

Structures of the catalytic domains of USP28 and USP25: USP28 is a constitutively active dimer and can bind and process ubiquitin (orange) at any time. In contrast, USP25 is a tetramer composed of two inter-linked USP28-like dimers (blue / gray and yellow / green) and this arrangement prevents binding of the substrate rendering the enzyme inactive. Credit: Rudolf Virchow Center of experimental biomedicine / University of Wuerzburg

 
 
 

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