Genetic Marker May Help Predict Risk of Ovarian Cancer
News May 28, 2012
Yale researchers had previously identified the gene known as KRAS-variant as valuable genetic marker to predict the risk of developing deadly ovarian cancer for women, however there had been conflicting evidence of its value in another study.
“This is more confirmatory evidence that this genetic test could aid women at risk of developing ovarian cancer by allowing them to make informed decisions about their health,” said Joanne B. Weidhaas, a study author and associate professor of therapeutic radiology who led the team that originally discovered the KRAS-variant.
An independent team of researchers led by scientists from Ohio State University looked for the variant in a group of women who had been diagnosed with both ovarian and breast cancer and also did not possess any other known markers for these cancers. The study found 39 percent of women in the study possessed the variant.
Other studies have also shown that the variant predicts how well patients respond to standard forms of chemotherapy and the outcome of their disease.
Research Team Discovers Compound that Stops Cancer From SpreadingNews
Using a mouse model, OHSU physician-scientists lead effort to hone a drug that inhibits cancer cells from spreading to other areas in the body.READ MORE
Targeting Epigenetic Proteins to Prevent Breast CancerNews
Researchers have discovered that epigenetic proteins promote the proliferation of mammary gland stem cells in response to the sex hormone progesterone. The study suggests that inhibiting these proteins with drugs could prevent the development of breast cancer in women at high risk of the disease.READ MORE
Targeting the Engine Room of the Cancer CellNews
Researchers at Columbia University Irving Medical Center (CUIMC) have developed a highly innovative computational framework that can support personalized cancer treatment by matching individual tumors with the drugs or drug combinations that are most likely to kill them.READ MORE