Immunicum Develops a Cancer Vaccine that Almost Doubled the Patients’ Survival
News Aug 11, 2015
Immunicum reports updated survival data from the Company's phase I/II study in patients with metastatic renal cancer treated with the cancer vaccine INTUVAX. Seven of the 11 patients evaluable for efficacy are still alive. Six of the 11 patients have received add-on treatment with some type of tyrosine kinase inhibitor. Median overall survival for the entire patient group is currently at 26.5 months versus expected 15.2 months (historical data for newly diagnosed patients with metastasized renal cell cancer receiving standard treatment with tyrosine kinase inhibitor Sutent/sunitinib). For the poor prognosis group (6 patients), the median overall survival is currently at 25.5 months versus expected 9 months and for patients with intermediate risk prognosis (5 patients), the median overall survival is currently at 32 months compared to expected 26 months. The final median overall survival has not yet been reached for any of the three patient groups.
It is very encouraging that the median overall survival for INTUVAX-treated renal cancer patients continues to increase. For the high-risk group, we note a current median overall survival that is close to tripled compared to the expected median overall survival for patients receiving standard treatment with sunitinib. We have now initiated a comprehensive phase II study in the same indication where we, thanks to the open design, expect to be able to provide a first status update around the end of the year, says Immunicum’s CEO, Jamal El-Mosleh.
The purpose of the phase I/II study was to document the safety profile and immunological effects, as well as to follow the survival of patients with metastatic renal cell cancer after two INTUVAX treatments.
Protein That Helps Keep Breast Cancer Dormant IdentifiedNews
A protein kinase that stops breast cancer cells growing and spreading has been outlined in new research.READ MORE
Anti-Inflammatory Pill Could Make Vaccines More Effective for the ElderlyNews
By identifying why skin immunity declines in old age, a UCL-led research team has found that an anti-inflammatory pill could help make vaccines more effective for elderly people.READ MORE
Combination Chemotherapy Could Significantly Improve Deadly Brain Tumor TreatmentNews
A team led by Massachusetts General Hospital (MGH) investigators has found that adding the chemotherapy drug hydroxyurea to the current chemotherapy protocol for glioblastoma significantly increased survival in animal models.READ MORE