Immunocore Named One of Fierce 15 Leading Biotechs of 2013
News Sep 26, 2013
Immunocore Limited has been named by FierceBiotech as one of 2013’s Fierce 15 biotechs, designating it as one of the most promising private biotechnology companies in the industry. This is Fierce Biotech’s eleventh annual Fierce 15 selection.
“Immunocore offers an interesting early-stage approach to rallying the immune system against cancer,” said FierceBiotech Executive Editor Ryan McBride. “Its T-cell receptor technology has taken many years to invent from scratch, and the hard work has begun to pay dividends with two recent pharma partnership deals.”
The company’s world-leading platform of bi-specific biological drugs, called ImmTACs (Immune mobilizing mTCR Against Cancer), exploit the power of T Cell Receptors (TCRs) to recognize intracellular changes that occur during cancer or viral infection.
This unique recognition ability of TCRs sets them apart from traditional antibody-based therapies that can only recognize changes on the surface of cells, and provides, for the first time, the ability to develop extremely potent targeted therapies for cancers that are poorly served.
A particular feature is that the ImmTACs can be directed to target and destroy only the cancerous cells, avoiding damage to healthy cells.
The most advanced ImmTAC drug, IMCgp100 for the treatment of melanoma, is in Phase I/II clinical trials in the UK and USA.
This summer, Immunocore announced two major partnership agreements with Genentech, a member of Roche Group, and GlaxoSmithKline to discover, develop and commercialize ImmTAC therapies against multiple targets.
James Noble, Chief Executive Officer of Immunocore, commented: “We are delighted to receive this prestigious award from FierceBiotech and be ranked among the top private biotech firms globally. This award recognizes 14 years of work to develop our technology and create a robust and reproducible platform, which has been validated through our two significant partnership deals, enabling our ImmTACs to be deployed as the basis of breakthrough treatments for cancers where there is a large unmet medical need.”
The Fierce 15 celebrates the spirit of being “fierce” - championing innovation and creativity, even in the face of intense competition.
An internationally recognized daily newsletter reaching more than 100,000 biotech and pharma industry professionals, FierceBiotech provides subscribers with an authoritative analysis of the day's top stories.
Every year FierceBiotech evaluates hundreds of private companies from around the world for its annual Fierce 15 list, which is based on a variety of factors such as the strength of its technology, partnerships, venture backers and a competitive market position.
A complete list of “Fierce 15” companies - the online newsletter’s eleventh annual selection - is available at www.fiercebiotech.com.
Mechanism Controlling Multiple Sclerosis Risk IdentifiedNews
Researchers at Karolinska Institutet have now discovered a new mechanism of a major risk gene for multiple sclerosis (MS) that triggers disease through so-called epigenetic regulation. They also found a protective genetic variant that reduces the risk for MS through the same mechanism.
Herpesvirus and Alzheimer's Link: High abundance of Herpes genes in postmortem Alzheimer's brain tissueNews
Data from three different brain banks to suggest that human herpesviruses are more abundant in the brains of Alzheimer's patients and may play a role in regulatory genetic networks that are believed to lead to the disease.READ MORE
Targeting Epigenetic Proteins to Prevent Breast CancerNews
Researchers have discovered that epigenetic proteins promote the proliferation of mammary gland stem cells in response to the sex hormone progesterone. The study suggests that inhibiting these proteins with drugs could prevent the development of breast cancer in women at high risk of the disease.READ MORE