Inherited Mutations May Predict Interval Breast Cancer
The study unravels the impact of rare genetic variants on interval breast cancers.
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An investigation conducted by researchers at Karolinska Institutet has led to a discovery in breast cancer diagnostics and treatments that could reshape screening programs and clinical approaches. The study, published in JAMA Oncology, unravels the impact of rare genetic variants on interval breast cancers, providing new insights into tailored screening strategies.
Interval cancers, a type of breast cancer diagnosed between routine screenings, have long posed challenges due to their aggressive nature and poorer patient outcomes compared with screen-detected cancers. However, until now, the role of genetic variants in these breast cancer types has been largely unexplored.
The study, involving 4121 breast cancer patients and 5631 controls, meticulously examined 34 breast cancer susceptibility genes. The primary focus was to discern the influence of carrying deleterious variants on differentiating between interval cancers and screen-detected cancers, taking mammographic density into consideration.
“Women with a family history of breast cancer, in combination with genetic variants in any of these 5 genes, were 4 times more likely to develop interval cancer compared with screen-detected breast cancer, suggesting that further large-scale sequencing efforts are necessary to uncover the full genetic contribution of the observed interaction,” says first author Juan Rodriguez, post-doctoral researcher at the Department of Medical Epidemiology and Biostatistics. Secondly, if a patient received a diagnosis of interval cancer, carriers of deleterious variants in any of these 5 genes had significantly worse survival compared with women not carrying any of them.
According to the researchers, this is the first report looking into the genetic differences between screen-detected and interval cancers using the 5 major genes for breast cancer. The results suggest that screen-detected and interval cancers are indeed distinct in both underlying genetics and biology, thus providing valuable information for identifying women who are at very high risk for developing aggressive breast cancer.
"These results show novel and important insights into the genomic differences between interval and screen-detected breast cancer”, stated Juan Rodriguez. “Our work clarifies the picture of what type of breast cancer is likely to evade detection in population-based screening programs, with potential applicability in clinical care and in future optimizations of screening programs aimed at lowering mortality”, continued Juan Rodriguez emphasizing the study's implications.
“Enriching the capacity to detect breast cancer at an earlier stage will ultimately lead to better treatment outcomes, an improved quality of life for affected women, and a reduction in the financial burden on the healthcare system”, says the study’s last author Professor Kamila Czene at the same department.
Reference: Rodriguez J, Grassmann F, Xiao Q, et al. Investigation of genetic alterations associated with interval breast cancer. JAMA Oncol. 2024. doi: 10.1001/jamaoncol.2023.6287
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