Molecular Profiling of Recurring Cancer Yields Success
Credit: Yale News
An analysis of a patient’s deadly brain tumor helped doctors at Smilow Cancer Hospital identify new emerging mutations and keep a 55-year old woman alive for more than five years, researchers report in the journal Genome Medicine.
The median survival rate for patients with glioblastoma multiform (GBM) is only 15 months, but three separate genomic analyses of the tumor identified new mutations that allowed doctors to adjust treatment and keep the patient alive for over five years, through two recurrences of the cancer.
“We were able to identify the molecular profile at each recurrence,” said Dr. Murat Günel, chair and the Nixdorff-German Professor in the Department of Neurosurgery, researcher with Yale Cancer Center, and senior author of the paper. “The molecular make-up of the cancer changed after each treatment and with time, but we were able to adjust treatments based on those profiles.”
For instance, the last genomic analysis revealed mutations of the cancer — under selective pressure from targeted therapies — had increased 30-fold, making the patient a good candidate for immunotherapy. Although there was an initial response, the cancer ultimately progressed.
The researchers were able to extend the findings on this case to more than 100 other GBM cases, leading to the observation that most GBMs change their genomic profile during therapy. “These findings have significant implications for precision treatment of these tumors” said Dr. Zeynep Erson Omay, the first author of the study and a research scientist in neurosurgery. “We now do a genetic analysis on every glioma surgically removed at Smilow Cancer Hospital during each recurrence or progression, comparing the molecular genomic profile to the original cancer to make treatment decisions.”
With new drugs available, there is hope that “we will soon start to see real changes in patient outcomes,” Gunel said.
Erson-Omay, E. Z., Henegariu, O., Omay, S. B., Harmancı, A. S., Youngblood, M. W., Mishra-Gorur, K., ... & Çağlar, C. (2017). Longitudinal analysis of treatment-induced genomic alterations in gliomas. Genome Medicine, 9(1), 12.
Using Snail Mail to Deliver Tests Boost Colorectal Cancer ScreeningNews
By sending tests in the post, researchers boost colorectal cancer screeningREAD MORE
Sex Differences Revealed: Heart Failure Death RatesNews
Death from heart failure in men and women compared in a study of over 90 000 patientsREAD MORE
Fetal Gene Therapy Prevents Lethal Neurodegenerative DiseaseNews
Researchers have successfully prevented the development of a fatal neurodegenerative disorder, Gaucher disease, using fetal gene therapy, in mice. The study highlights the potential of using this approach to combat lethal neurodegenerative diseases affecting newborns.READ MORE
Like what you just read? You can find similar content on the communities below.Cell Science Diagnostics Drug Discovery Genomics Research Informatics Neuroscience Immunology & Microbiology
To personalize the content you see on Technology Networks homepage, Log In or Subscribe for FreeLOGIN SUBSCRIBE FOR FREE