Pre-Clinical Safety in Cancer Drug Development: “Attitude to Safety Needs to Change”
Many companies involved in cancer drug research and development need to re-think their use of safety data in helping to bring new drugs to cancer patients.
Dr Richard Knight of Alderley Park-based ApconiX will tell this month’s conference, Accelerating Cancer Drug Development – from target to patients, that greater focus on pre-clinical safety should be fundamental to the development of new cancer therapies.
He said: “There is still huge unmet need in effective cancer treatment and it can be tempting for companies researching new drugs to focus mainly on efficacy data with safety issues relegated to secondary importance. However, an improved safety profile is not only an important way to reduce the high rate of drug failure, it can also expedite clinical trials and, above all, it’s the best thing to do for patients.
“With most cancer drugs, patients have to put up with a wide range of adverse effects in return for promised benefits. But that shouldn’t mean patients having to tolerate side effects that could potentially be designed out in the research stage when companies are choosing between candidate chemicals.”
Dr Knight will outline his views as part of the Accelerating Cancer Drug Development conference at Alderley Park on 27 February. Currently more than 50% of ApconiX’s non-clinical safety work is involved with oncology drug development.
“Eliminating pre-clinical safety signals makes everything else easier, from patient recruitment to speed and overall cost. It’s a positive attribute and companies should be taking every opportunity to advance the compound with the best overall profile.
“There is a widespread misunderstanding about what pre-clinical safety is there to do. Many see it largely as a box-ticking exercise but it can be of real value in moving new agents rapidly through clinical trials.”
This article has been republished from materials provided by ApconiX. Note: material may have been edited for length and content. For further information, please contact the cited source.
High Fruit and Veg Consumption May Reduce Breast Cancer RiskNews
Women who eat a high amount of fruits and vegetables each day may have a lower risk of breast cancer, especially of aggressive tumors, than those who eat fewer fruits and vegetables, according to a new study led by researchers from Harvard T.H. Chan School of Public Health.READ MORE
Kidney Cancer Driver Could Lead to New Treatment StrategyNews
Scientists have uncovered a potential therapeutic target for kidney cancers that have a common genetic change. Scientists have known this genetic change can lead to an overabundance of blood vessels, which help feed nutrients to the tumors. Their latest finding shows a potential new cancer-driving pathway.READ MORE
Why Might Super-Tasters be at Higher Cancer Risk?News
High bitter-taste sensitivity is associated with a significantly increased risk of cancer in older British women, according to researchers who conducted a unique study of 5,500 women whose diet, lifestyle and health has been tracked for about 20 years.READ MORE