We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Advertisement

Study Links Salmonella Exposure to Colon Cancer Risk

A digitally colorized scanning electron microscopic image showing a number of red-colored, Salmonella sp. bacteria, as they were in the process of invading a mustard-colored, ruffled, immune cell.
This digitally colorized scanning electron microscopic (SEM) image, depicts a number of red-colored, Salmonella sp. bacteria, as they were in the process of invading a mustard-colored, ruffled, immune cell. Credit: National Institute of Allergy and Infectious Diseases (NIAID)

Want a FREE PDF version of This News Story?

Complete the form below and we will email you a PDF version of "Study Links Salmonella Exposure to Colon Cancer Risk"

Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our Privacy Policy

Read time:
 

A new study published in the journal Cell Reports Medicine links exposure to salmonella bacteria to colon cancer risk.


The researchers, including a team led by Jun Sun from the University of Illinois Chicago, studied human colon cancer tissue samples and animal models and found that exposure to salmonella was linked with colon cancers that developed earlier and grew larger. 


The study authors first looked at data from a Netherlands-based retrospective study of colon cancer patients that found tissue samples taken during routine colon cancer surgery with salmonella antibodies tended to be from people who had worse colon cancer outcomes.

Want more breaking news?

Subscribe to Technology Networks’ daily newsletter, delivering breaking science news straight to your inbox every day.

Subscribe for FREE

Using salmonella strains isolated from these tissue samples, Sun and her U.S.-based team studied mice with colon cancer that had been exposed to the bacteria. They observed accelerated tumor growth and larger tumors in mice with salmonella exposure. They also saw that there was increased salmonella translocated to the tumors.


“During infection, salmonella hijacks essential host signaling pathways, and these molecular manipulations may cause oncogenic transformation. The current study tells us that more research is needed into the connection between salmonella exposure and colon cancer risk in the USA, and that simply by practicing safe food preparation, we can potentially help to protect ourselves,” said Sun, UIC professor of medicine.


Sun’s collaborators in the Netherlands also studied the bacteria in vitro. They combined human cancer cells and pre-cancer cells with the salmonella strain in the lab and measured any growth or changes in the tumor. They saw that even one infection caused transformation and that each salmonella infection exponentially increased the rate of cell transformation.


“The mouse and tissue culture experiments show that salmonella infection had a chronic effect to accelerate tumor growth,” said Sun, who also is a member of the University of Illinois Cancer Center at UIC. “This evidence tells us that we need to look closer at salmonella exposure as an environmental risk factor for chronic diseases, such as colon cancer.”


Leiden University Medical Center, the National Institute for Public Health and the Environment, and Utrecht University, all in the Netherlands, collaborated on this study.  


Reference: Elsland DM van, Duijster JW, Zhang J, et al. Repetitive non-typhoidal Salmonella exposure is an environmental risk factor for colon cancer and tumor growth. CR Med. 2022;3(12). doi: 10.1016/j.xcrm.2022.100852


This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.


Advertisement