Ubiquitous and Influential

News   Feb 15, 2017 | Original story from Julius-Maximilians-Universität Würzburg

 
Ubiquitous and Influential

Metaphorical representation of the regulatory mechanism of the ubiquitin ligase HUWE1. The dimer form of HUWE1, as mediated by the molecular “thumb” and “pointer” regions, is inactive. In contrast, single molecules of HUWE1 in the active form assemble ubiquitin chains - through yet unknown mechanisms. (Graphic: Katharina Beer)

 
 
 

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