What Happens when we Sunburn
News Jul 10, 2012
The findings open the way to perhaps eventually blocking the inflammatory process, the scientists said, and have implications for a range of medical conditions and treatments.
"For example, diseases like psoriasis are treated by UV light, but a big side effect is that this treatment increases the risk of skin cancer," said principal investigator Richard L. Gallo, M.D., Ph.D., professor of medicine at UC San Diego School of Medicine and Veterans Affairs San Diego Healthcare System. "Our discovery suggests a way to get the beneficial effects of UV therapy without actually exposing our patients to the harmful UV light. Also, some people have excess sensitivity to UV light, patients with lupus, for example. We are exploring if we can help them by blocking the pathway we discovered."
Using both human skin cells and a mouse model, Gallo, first author Jamie J. Bernard, a postdoctoral researcher, and colleagues found that UVB radiation fractures and tangles elements of non-coding micro-RNA — a special type of RNA inside the cell that does not directly make proteins. Irradiated cells release this altered RNA, provoking healthy, neighboring cells to start a process that results in an inflammatory response intended to remove sun-damaged cells.
We see and feel the process as sunburn.
"The inflammatory response is important to start the process of healing after cell death," said Gallo. "We also believe the inflammatory process may clean up cells with genetic damage before they can become cancer. Of course, this process is imperfect and with more UV exposure, there is more chance of cells becoming cancerous."
Gallo said it's still not known how gender, skin pigmentation and individual genetics may affect the mechanism of sunburn. "Genetics is closely linked to the ability to defend against UV damage and develop skin cancers," he said. "We know in our mouse genetic models that specific genes will change how the mice get sunburn. Humans have similar genes, but it is not known if people have mutations in these genes that affect their sun response."
In treating inflammatory bowel disease (IBD), physicians can have a hard time telling which newly diagnosed patients have a high risk of severe inflammation or what therapies will be most effective. Now researchers report finding an epigenetic signature in patient cells that appears to predict inflammation risk in a serious type of IBD called Crohn’s disease.