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Latest Posters
Protein array-based screening of autoantibody signatures
Poster

Protein array-based screening of autoantibody signatures

The evidence for an association between autoimmune diseases and chronic HCV infection has been clearly established. To this aim, a protein array was employed to analyze serum samples of HCV patients w/wo autoimmune complications, of patients with autoimmune hepatitis but not infected with HCV and of healthy donors as controls. A panel of autoantigens able to discriminate among the three groups of patients was identified for potential use as biomarkers.
Profiling formalin-fixed, paraffin-embedded (FFPE) samples on three Agilent microarray platforms
Poster

Profiling formalin-fixed, paraffin-embedded (FFPE) samples on three Agilent microarray platforms

Thousands of formalin-fixed, paraffin-embedded (FFPE) samples from clinical archives are available for retrospective studies. Such samples could provide crucial information for drug target discovery and diagnostics of various diseases. Here we used FFPE samples and their matched fresh-frozen (FF) counterparts to examine their performance on three types of microarrays including whole genome expression, comparative genomic hybridization (CGH) and microRNA.
Profiling formalin-fixed, paraffin-embedded (FFPE) samples on three Agilent microarray platforms
Poster

Profiling formalin-fixed, paraffin-embedded (FFPE) samples on three Agilent microarray platforms

Thousands of formalin-fixed, paraffin-embedded (FFPE) samples from clinical archives are available for retrospective studies. Such samples could provide crucial information for drug target discovery and diagnostics of various diseases. Here we used FFPE samples and their matched fresh-frozen (FF) counterparts to examine their performance on three types of microarrays including whole genome expression, comparative genomic hybridization (CGH) and microRNA.
Geneset-based cancer survival analysis: On the non-uniform distributiuon of p-values under the null hypothesis
Poster

Geneset-based cancer survival analysis: On the non-uniform distributiuon of p-values under the null hypothesis

Although null p-values are assumed to be uniformly distributed in gene expression experiments, the actual distribution often deviates from the assumed distribution. This can incorrectly associate the biology of a geneset with cancer prognosis in geneset-based survival studies. To assess the implications of this, a geneset-based method was developed. This method empirically approximates the distribution of null p-values and tests whether predefined sets of biologically-related genes are associate
Point-of-care testing for prostate cancer diagnosis
Poster

Point-of-care testing for prostate cancer diagnosis

This presentation describes the potential of using a new fully automated QCM biosensor and a commercial SPR biosensor for the detection of PSA, a biomarker for prostate cancer. Initially a new buffer was formulated to eliminate 98% of the non-specific human serum protein binding to the sensors. Obtained results indicate that both instruments can be used for the fast and easy detection of PSA (0.29-150 ng/ml) in serum.
A Web Interface for Automatic Microarray Analysis
Poster

A Web Interface for Automatic Microarray Analysis

DNA-Microarray technology provides a diagnostic tool for studying cancer and genetic diseases, allowing the experimenter to identify disease related genes and predict the tumour type for new cell samples. However, the statistical analysis of microarray data is a time-consuming and error-prone process. To address this problem we have developed a web interface for automatic DNA-microarray analysis, ArrayMining.net, which guides the user through the analysis process and performs automatic parameter
Resorufin - a lead for a new protein kinase CK2 inhibitor
Poster

Resorufin - a lead for a new protein kinase CK2 inhibitor

Screening of a natural compound library led to the identification of resorufin, as a highly selective and potent inhibitor for protein kinase CK2. Out of 52 kinases tested only CK2 was inhibited. The IC50 values determined for the CK2 holoenzymes were 1.5 µM and for the free catalytic subunits ca. 4 µM. In different cancer cell lines treatment with resorufin led to cell death and endogenous CK2 was inhibited.
SESTAMIBI SCAN FOR HYPERPARATHYROIDISM, AN ASSESSMENT OF PERFORMANCE
Poster

SESTAMIBI SCAN FOR HYPERPARATHYROIDISM, AN ASSESSMENT OF PERFORMANCE

To calculate the sensitivity, specificity and positive predictive value of 99 Tc Sestambi scan in the localization of parathyroid disease and to calculate the cost benefit of routine pre-operative scan.
SESTAMIBI SCAN FOR HYPERPARATHYROIDISM, AN ASSESSMENT OF PERFORMANCE
Poster

SESTAMIBI SCAN FOR HYPERPARATHYROIDISM, AN ASSESSMENT OF PERFORMANCE

To calculate the sensitivity, specificity and positive predictive value of 99 Tc Sestambi scan in the localization of parathyroid disease and to calculate the cost benefit of routine pre-operative scan.
SESTAMIBI SCAN FOR HYPERPARATHYROIDISM, AN ASSESSMENT OF PERFORMANCE
Poster

SESTAMIBI SCAN FOR HYPERPARATHYROIDISM, AN ASSESSMENT OF PERFORMANCE

To calculate the sensitivity, specificity and positive predictive value of 99 Tc Sestambi scan in the localization of parathyroid disease and to calculate the cost benefit of routine pre-operative scan.

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