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Latest Posters
qPCRas a primary screen in drug discovery
Poster

qPCRas a primary screen in drug discovery

We report the use of qPCR technique to follow the thermal unfolding of proteins by the binding of the dye SYPRO Orange, and exploit its potential as a robust and high-throughput primary screen for small molecule drug discovery.
Targeting Inflammatory Cytokines Using Adenoviruses: gene delivery of biological therapies in ovarian cancer
Poster

Targeting Inflammatory Cytokines Using Adenoviruses: gene delivery of biological therapies in ovarian cancer

Constitutive TNF-alpha expression is characteristic of the malignant ovarian surface epithelium. Adenoviral mutants hold great promise as gene therapy vectors but their efficacy is hindered by an inflammatory cascade orchestrated by TNF-alpha. We found that delivering TNF-alpha shRNA to ovarian cancer cells using oncolytic adenoviruses could reduce the inflammatory cascade generated by adenoviruses and also had direct anti-tumour activity on the cancer cells.
INSULINOMAS  – EXPERIENCE FROM AN INSTITUTION IN SOUTH INDIA
Poster

INSULINOMAS – EXPERIENCE FROM AN INSTITUTION IN SOUTH INDIA

Background: Insulinoma is a disorder affecting one in 100,000 of the general population. The clinical profile of insulinomas among Indian patients has not been characterized. Aim of the study: To study the clinical characteristics, biochemical and radiological parameters and treatment aspects of adult patients with insulinomas. Methodology: A retrospective analysis of 18 patients with insulinoma who were treated from 1992 to 2004
INSULINOMAS  – EXPERIENCE FROM AN INSTITUTION IN SOUTH INDIA
Poster

INSULINOMAS – EXPERIENCE FROM AN INSTITUTION IN SOUTH INDIA

Background: Insulinoma is a disorder affecting one in 100,000 of the general population. The clinical profile of insulinomas among Indian patients has not been characterized. Aim of the study: To study the clinical characteristics, biochemical and radiological parameters and treatment aspects of adult patients with insulinomas. Methodology: A retrospective analysis of 18 patients with insulinoma who were treated from 1992 to 2004
INSULINOMAS  – EXPERIENCE FROM AN INSTITUTION IN SOUTH INDIA
Poster

INSULINOMAS – EXPERIENCE FROM AN INSTITUTION IN SOUTH INDIA

Background: Insulinoma is a disorder affecting one in 100,000 of the general population. The clinical profile of insulinomas among Indian patients has not been characterized. Aim of the study: To study the clinical characteristics, biochemical and radiological parameters and treatment aspects of adult patients with insulinomas. Methodology: A retrospective analysis of 18 patients with insulinoma who were treated from 1992 to 2004
DOCKING STUDIES OF A NEW HETEROCYCLIC METHYLTHIOMORPHOLIN PHENOLS DERIVATIVES AS ANTIHYPERTENSIVE DRUGS WITH ACE TARGET.CASE FESCDIPINE II
Poster

DOCKING STUDIES OF A NEW HETEROCYCLIC METHYLTHIOMORPHOLIN PHENOLS DERIVATIVES AS ANTIHYPERTENSIVE DRUGS WITH ACE TARGET.CASE FESCDIPINE II

As part of the Drug Design in Medicinal Chemistry Program of the UNAM, new methylthiomorpholinphenol compounds with cardiovascular effect, were studied. One of them, FESCDIPINE II, was an excellent antihypertensive drug, that has low toxicity and preliminary studies indicate that the Angiotensin-converting enzyme (ACE) system is the biological target of this compound.
THE OSTEOPROTECTIVE ACTION OF 6-OXA-8a-ANALOGUES OF STEROID ESTROGENS
Poster

THE OSTEOPROTECTIVE ACTION OF 6-OXA-8a-ANALOGUES OF STEROID ESTROGENS

We synthesized fourteen 6-oxa-8a-estrogens analogues and investigated osteoprotective and uterotropic actions. We demonstrated correlation: every modification in structure of 6-oxa-8-analogues leading to strong (>30%) reduction of uterotropic action induces slump of osteoprotective activity. This allows to make conclusion: main biotarget, responsible for appearance of osteoprotective action is a-estrogen receptor. We found steroid estrogen analogues with cholesterol-lowering properties without u
SOME BIOLOGICAL PROPERTIES OF TRITERPENOID ACIDS
Poster

SOME BIOLOGICAL PROPERTIES OF TRITERPENOID ACIDS

Ursolic and betulinic acids acids induce the processes of apoptosis. We tested the risk of osteoporosis induction under influence of triterpenoids, since they can interact with glucocorticoid receptors. In experiments on oviriectomized rats we found that acids do not show any negative influence on percentage of mineral components in the femur and have cholesterol-lowering action under experimental conditions.
Effects of cannabinoids on cholinergic-mediated contraction of human bronchi
Poster

Effects of cannabinoids on cholinergic-mediated contraction of human bronchi

The current study was performed to investigate the role of cannabinoid (CB) receptors on the cholinergic contraction of isolated human airways. Results obtained with WIN55,212-2 (CB1/CB2 agonist), JWH-133 (CB2 agonist) and CB receptor selective antagonists suggest that CB1-receptor stimulation inhibits the cholinergic contraction in human isolated bronchi through stimulation of prejunctional receptors, located to post-ganglionic cholinergic nerves.
DISTRIBUTION OF SAa2,6GAL AND SAa2,3GAL LINKED SURFACE RECEPTORS IN HUMAN RESPIRATORY TRACT AND ASSOCIATION WITH INFLUENZA VIRUS REPLICATION
Poster

DISTRIBUTION OF SAa2,6GAL AND SAa2,3GAL LINKED SURFACE RECEPTORS IN HUMAN RESPIRATORY TRACT AND ASSOCIATION WITH INFLUENZA VIRUS REPLICATION

To investigate the level of SAa2,6Gal and a2,3Gal linked receptors on human bronchial epithelial cells, and relate this to the ability of both human and avian influenza viruses to infect bronchial epithelial cells

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