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Latest Posters
A genome-wide loss of function screen identifies new genes required for lung cancer cell proliferation
Poster

A genome-wide loss of function screen identifies new genes required for lung cancer cell proliferation

RNA interference (RNAi) provides an experimental tool for functional genomics analysis. We screened a genome-wide RNAi library to identify new genes involved in lung cancer cell proliferation. 72 % from the 257 genes identified were involved in general gene expression processes, 16 % were of unknown function or unrelated to proliferation, and 12% consisted of uncharacterized genes. These last sets of genes provide potential novel targets for lung cancer treatment.
Expression of stress response protein GRP78 is associated with the development of castration-resistant prostate cancer
Poster

Expression of stress response protein GRP78 is associated with the development of castration-resistant prostate cancer

This study investigated the role of the GRP78 in prostate cancer progression and the development of castration-resistant prostate cancer, where cancer cells continue to survive despite the stress of an androgen-starved environment.
Application of genetic programming in analysis of quantitative gene expression profiles for identification of nodal status in bladder cancer
Poster

Application of genetic programming in analysis of quantitative gene expression profiles for identification of nodal status in bladder cancer

Nodal involvement in bladder cancer is an independent indicator of prognosis. This study employed an iterative machine learning process called genetic programming on quantitative expression values of 70 genes to classify primary urothelial carcinoma samples into those associated with or without nodal metastasis. The generated rules showed a strong predilection for ICAM1, MAP2K6 and KDR resulting in gene expression motifs that cumulatively suggested a pattern ICAM1>MAP2K6>KDR for node positive ca
New Protein Biomarkers for Histopathological Classification of Breast Cancer
Poster

New Protein Biomarkers for Histopathological Classification of Breast Cancer

We used Ciphergen technology based on SELDI TOF-MS (Surface Enhanced Laser Desorption/Ionisation Time-of-Flight Mass Spectrometry) for analysis of protein expression profiles of 105 breast cancer tissue samples. The aim of this study was the identification of single proteins or protein patterns specific for different tumour subgroups, which should take advantage of the biomarker as an alternative to commonly used diagnostic and prognostic characteristics.
Inflammatory Markers in Leg Ulcer Fluid from Chronic Venous Insufficiency
Poster

Inflammatory Markers in Leg Ulcer Fluid from Chronic Venous Insufficiency

The purpose of our study was to evaluate soluble matrixmetalloproteinases (MMPs) and their inhibitor (TIMP1) associated to leg ulcer wound fluid in comparison with the tissue localized ones. We aimed to develop an easy-to-perform protocol for the quantification of soluble MMPs / TIMP and associate the obtained levels with the disease stage and prognostic.
Biomarker Discovery Strategy for Trisomy 21 Using iTRAQ and 4800 Plus MALDI TOF/TOF
Poster

Biomarker Discovery Strategy for Trisomy 21 Using iTRAQ and 4800 Plus MALDI TOF/TOF

Plasma proteins serve as good indicators of disease as there are representative proteins from several cellular processes and thus a potential source for biomarker discovery. The large dynamic range of plasma proteins makes the analysis very challenging, as a large number of low abundance proteins are masked by a few high abundance proteins.
Two-Dimensional Molecular Profiling of Multiple Myeloma
Poster

Two-Dimensional Molecular Profiling of Multiple Myeloma

We have compared two different solubilization buffers, we also evaluated protein precipitation with ethanol and optimized 2-DE conditions for human myeloma proteins.
Antibody Array-Based Analysis of Expression Levels in Protein Mixtures Extracted from Formalin-Fixed Paraffin-Embedded (FFPE) Material using ULS Labeling
Poster

Antibody Array-Based Analysis of Expression Levels in Protein Mixtures Extracted from Formalin-Fixed Paraffin-Embedded (FFPE) Material using ULS Labeling

Protein was extracted from 7-year old FFPE samples of B-cell lymphoma and mamma carcinoma, followed by ULS labeling. Samples were used for single or two color assays using a custom-made antibody array. We observed differential expression levels for several captured analytes. In B-cell lymphoma, expected high levels of IgM were detected, while high levels of CA19-9, a putative marker, were found for the breast cancer tissue.
Antibody Array-Based Analysis of Expression Levels in Protein Mixtures Extracted from Formalin-fFxed Paraffin-Embedded (FFPE) Material using ULS Labeling
Poster

Antibody Array-Based Analysis of Expression Levels in Protein Mixtures Extracted from Formalin-fFxed Paraffin-Embedded (FFPE) Material using ULS Labeling

Protein was extracted from 7-year old FFPE samples of B-cell lymphoma and mamma carcinoma, followed by ULS labeling. Samples were used for single or two color assays using a custom-made antibody array. We observed differential expression levels for several captured analytes. In B-cell lymphoma, expected high levels of IgM were detected, while high levels of CA19-9, a putative marker, were found for the breast cancer tissue.
2-DE Analysis of Breast Cancer Cell Lines MDA-1833 and MDA-4175 with Distinct Metastatic Organ-Specific Potentials and Comparison with Parental Cell Line MDA-MB-231
Poster

2-DE Analysis of Breast Cancer Cell Lines MDA-1833 and MDA-4175 with Distinct Metastatic Organ-Specific Potentials and Comparison with Parental Cell Line MDA-MB-231

Breast cancer has diverse metastatic behavior. Subpopulations of cells with enhanced metastatic abilities either to bone (1833) or to lung (4175) have been isolated by the group of J. Massague by in vivo selection of MDA-MB-231 cells. We performed the 2-DE analysis of the cell lines. We have found and identified 11 differentially expressed protein spots.

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