Latest Posters
Poster
BAP1 Immunohistochemistry and p16 FISH in the Diagnosis of Malignant Peritoneal Mesothelioma
In order to differentiate peritoneal malignant mesothelioma (PMM) from primary peritoneal serous carcinoma (PPSC) and reactive mesothelial hyperplasia (RMH), we used immunohistochemistry to examine for BAP1, and FISH to examine for homozygous deletion of p16.
Poster
Comparison of Key Signaling Pathways in Lung Cancer Cells Grown in 2D and 3D Formats
Evaluation of Wnt/ß-catenin and BMP pathway proteins and gene expression in NSCLC cell lines A549 and H460 in 2D and 3D cultures.
Poster
Resistance-Associated Variants in HCV Genotype 1 Populations
In this study we specifically investigated RAVs emerging in HCV genotype 1.
Poster
Assessment of the Anti-angiogenic Effect of VEGFR2 siRNA in Clonetics™ HUVEC using the Lonza 4D-Nucleofector™ System
In the current study we have used siRNA targeting VEGFR2 as an example to study knockdown of VEGFR2 and subsequent inhibition of tube formation by HUVECs on Growth Factor Reduced Matrigel™ in a 96-well plate format. The same strategy can be used for screening and validating siRNA based inhibitors of the angiogenic process in vitro and thus could be of utility in anti-cancer screening strategies.
Poster
Clinical Applications of “Liquid Biopsy” in the Colorectal Cancer Treatment
Liquid biopsy provides a circulating biomarker not only for treatment response but decision making of a sequential strategy.
Poster
600 Base Reads on the Ion S5™ Next-Generation Sequencing System Enables Accurate HLA Typing of 96 Samples on One 530™ Chip
We have demonstrated that by combining improvements in templating and sequencing biochemistry we are able to sequence templates longer than 600 bases with high accuracy on an Ion S5 530 chip.
These improvements open the S5 use space to include haplotyping applications that require longer reads. As a demonstration of that, we accurately typed 96 HLA samples on one 530 chip.
These improvements open the S5 use space to include haplotyping applications that require longer reads. As a demonstration of that, we accurately typed 96 HLA samples on one 530 chip.
Poster
Metabolic Response to Everolimus in Patient-derived Xenografts of Triple Negative Breast Cancer
Everolimus treatment metabolic effects on TNBC PDX models were investigated using MR spectroscopy. PLS-DA successfully discriminated treated from controls and PDX expressing INPP4B and not. LMM revealed significant differences in 4/17 metabolites and two metabolite ratios between treated and controls.
Poster
The Challenges of Genetic Testing in Patients Diagnosed with Breast Cancer; The Kent Oncology Centre Experience
In this study we explore retrospective data to determine strategies for optimizing the genetic referral pathways for breast cancer.
Poster
CellTiter-Glo® 2.0: A Novel Luminescent Cell Viability Assay with Greatly Enhanced Storage Stability
Here we report on the attributes of a novel ATP detection reagent for cell viability with all of the assay performance of the previous CellTiter-Glo® Reagent, but now with markedly enhanced stability as a single component in a liquid format. These new features provide for much greater ease-of-use in that storage of the reagent at 4°C eliminates the requirement for reagent thawing and minimizes temperature equilibration time.
Poster
Knockdown of p53 by Accell Self-delivering siRNA Causes Inhibition of p53-dependent DNA Damage Response in IMR-32 Neuroblastoma Cell Line and β-amyloid Toxicity in Rat Cortical Neurons
Here we describe how application of Accell siRNA enabled the development of a high content screening assay in IMR-32 neuroblastoma cells and a whole culture cell viability assay in primary rat cortical neurons.
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