We've updated our Privacy Policy to make it clearer how we use your personal data. We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Advertisement

Latest Posters

Inecalcitol Stimulates CD38 Expression in Multiple Myeloma and Acute Myeloid Leukemia Cell Lines content piece image
Poster

Inecalcitol Stimulates CD38 Expression in Multiple Myeloma and Acute Myeloid Leukemia Cell Lines

Inecalcitol is a vitamin D receptor agonist currently in Phase II clinical trial in AML (acute myeloid leukemia). Inecalcitol increases the expression of CD38 at the surface of 5 multiple myeloma cell lines; therefore, inecalcitol could potentiate the clinical response of MM patients to a therapeutic anti-CD38 antibody
Inecalcitol induces the expression of the CD38 antigen at the surface of 4 AML cell lines; thus, inecalcitol could render AML patients sensitive to a therapeutic anti-CD38.
Functional Analysis of RAD51B and RAD23B SNPs using Circular Chromosome Conformation Capture (4C) in Human Prostate Cell Lines content piece image
Poster

Functional Analysis of RAD51B and RAD23B SNPs using Circular Chromosome Conformation Capture (4C) in Human Prostate Cell Lines

The aim of this study is to understand the mechanism behind the association between single nucleotide polymorphisms (SNPs), lying in non-coding regions near or within RAD51B and RAD23B, and prostate cancer risk by analysing their interactions with the whole genome using Circular Chromosome Conformation Capture (4C).
BAP1 Immunohistochemistry and p16 FISH in the Diagnosis of Malignant Peritoneal Mesothelioma content piece image
Poster

BAP1 Immunohistochemistry and p16 FISH in the Diagnosis of Malignant Peritoneal Mesothelioma

In order to differentiate peritoneal malignant mesothelioma (PMM) from primary peritoneal serous carcinoma (PPSC) and reactive mesothelial hyperplasia (RMH), we used immunohistochemistry to examine for BAP1, and FISH to examine for homozygous deletion of p16.
Comparison of Key Signaling Pathways in Lung Cancer Cells Grown in 2D and 3D Formats content piece image
Poster

Comparison of Key Signaling Pathways in Lung Cancer Cells Grown in 2D and 3D Formats

Evaluation of Wnt/ß-catenin and BMP pathway proteins and gene expression in NSCLC cell lines A549 and H460 in 2D and 3D cultures.
Resistance-Associated Variants in HCV Genotype 1 Populations content piece image
Poster

Resistance-Associated Variants in HCV Genotype 1 Populations

In this study we specifically investigated RAVs emerging in HCV genotype 1.
Assessment of the Anti-angiogenic Effect of VEGFR2 siRNA in Clonetics™ HUVEC using the Lonza 4D-Nucleofector™ System content piece image
Poster

Assessment of the Anti-angiogenic Effect of VEGFR2 siRNA in Clonetics™ HUVEC using the Lonza 4D-Nucleofector™ System

In the current study we have used siRNA targeting VEGFR2 as an example to study knockdown of VEGFR2 and subsequent inhibition of tube formation by HUVECs on Growth Factor Reduced Matrigel™ in a 96-well plate format. The same strategy can be used for screening and validating siRNA based inhibitors of the angiogenic process in vitro and thus could be of utility in anti-cancer screening strategies.
Clinical Applications of “Liquid Biopsy” in the Colorectal Cancer Treatment content piece image
Poster

Clinical Applications of “Liquid Biopsy” in the Colorectal Cancer Treatment

Liquid biopsy provides a circulating biomarker not only for treatment response but decision making of a sequential strategy.
600 Base Reads on the Ion S5™ Next-Generation Sequencing System Enables Accurate HLA Typing of 96 Samples on One 530™ Chip content piece image
Poster

600 Base Reads on the Ion S5™ Next-Generation Sequencing System Enables Accurate HLA Typing of 96 Samples on One 530™ Chip

We have demonstrated that by combining improvements in templating and sequencing biochemistry we are able to sequence templates longer than 600 bases with high accuracy on an Ion S5 530 chip.
These improvements open the S5 use space to include haplotyping applications that require longer reads. As a demonstration of that, we accurately typed 96 HLA samples on one 530 chip.
Metabolic Response to Everolimus in Patient-derived Xenografts of Triple Negative Breast Cancer content piece image
Poster

Metabolic Response to Everolimus in Patient-derived Xenografts of Triple Negative Breast Cancer

Everolimus treatment metabolic effects on TNBC PDX models were investigated using MR spectroscopy. PLS-DA successfully discriminated treated from controls and PDX expressing INPP4B and not. LMM revealed significant differences in 4/17 metabolites and two metabolite ratios between treated and controls.
The Challenges of Genetic Testing in Patients Diagnosed with Breast Cancer; The Kent Oncology Centre Experience content piece image
Poster

The Challenges of Genetic Testing in Patients Diagnosed with Breast Cancer; The Kent Oncology Centre Experience

In this study we explore retrospective data to determine strategies for optimizing the genetic referral pathways for breast cancer.
Advertisement