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Analyzing Tumor Heterogeneity With Mass Spectrometry and Spatial Biology

Tumor Microenvironment
Credit: iStock

Glioblastoma (GBM) is a common and highly malignant type of primary brain tumor. The tumor microenvironment (TME) is critical for better understanding the metabolic state of cells, and therefore the downstream effects on treatment, including chemotherapeutic agents.

Until now, spatial understanding of GBM metabolomic and lipidomic profiles have been limited by a lack of available research tools. 

This poster highlights the latest mass spectrometry and spatial biology solutions for GBM tissue analysis, offering critical insights into the metabolic signatures and immune cell infiltration of this tissue type. 

Download this poster to discover: 

  • A method of analysis that can reveal changes in lipid regulation for healthy vs disease-state
  • Contextualizing traditional LC-MS with spatial information
  • An innovative spatial biology workflow that can add meaningful spatial protein information

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