Applications of Mass Spectrometry Targeted Assays for Quantitative Analysis of Cancer Signaling Proteins
Poster Oct 21, 2019
Penny Jensen; Bhavin Patel; Leigh Foster; Aaron Gajadhar; Sebastien Gallien; Jonathan R. Krieger; Jiefei Tong; Michael F. Moran; Rosa Viner; Andreas Huhmer; Kay Opperman; John Rogers
The AKT/mTOR pathway and the proteins involved play a central role in tumor progression and drug resistance. Quantitative measurement of alterations in the expression of pathway proteins and post-translational modifications (PTMs) is necessary for understanding cancer biology. However, highly accurate monitoring of these pathway proteins has not been achieved.
Download this poster to discover more about the analysis of pathway proteins, including:
- Why their analysis has been inaccurate.
- How to achieve accuracy using mass spectrometry.
- How multiple pathway proteins can be quantified simultaneously.