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Cancer Research

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Effects of cannabinoids on cholinergic-mediated contraction of human bronchi

Poster

Published: March 31, 2008

Effects of cannabinoids on cholinergic-mediated contraction of human bronchi content piece image

The current study was performed to investigate the role of cannabinoid (CB) receptors on the cholinergic contraction of isolated human airways. Results obtained with WIN55,212-2 (CB1/CB2 agonist), JWH-133 (CB2 agonist) and CB receptor selective antagonists suggest that CB1-receptor stimulation inhibits the cholinergic contraction in human isolated bronchi through stimulation of prejunctional receptors, located to post-ganglionic cholinergic nerves.