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Restoring T Cell Function in Exhausted T Cells

Demonstrating Restoration of T Cell Function in Exhausted T Cells With IKZF3 Small Molecule Inhibitor, Lenalidomide

T cells can develop an exhausted phenotype due to prolonged antigen stimulation, resulting in reduced proliferative potential and loss of cytotoxic funtion. This can occur within the tumor microenvironment, allowing cancer cells to escape immune surveillance. 

Download this poster to discover a model that can be used to assess the ability of candidate immuno-oncology therapeutics to:

  • Rescue exhausted T cell phenotypes
  • Restore T cell function
  • Permit tumor cell clearance