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Efficient Transduction of CAR Into T Cells

T cells attacking a cancer cell.

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AMSBIO announce a new range of high-titer Chimeric Antigen Receptor (CAR) lentivirus that provide high transduction efficiency with long-term, stable expression in resting and actively dividing cells.


Personalized treatment for cancer reached a new milestone in 2017 with the FDA approval of CAR-T cells for treatment of leukemia and lymphoma. Consequently, there is now rapid growth in research on the therapeutic uses of CAR-T cells.


Increasingly CAR-T cell therapies are being employed as a strategy to redirect a patient’s T-cells to target and destroy specific tumor cells. Researchers have found that viral vectors are the most effective way of transducing CAR into T cells as part of a CAR-T cell manufacturing process.


Due to their ability to stably integrate large DNA inserts, and to efficiently transduce both dividing and non-dividing cells, AMSBIO’s new range of clinical grade CAR lentivirus offers the perfect tool to generate CAR-T cells ex-vivo.


A comprehensive line of CAR lentivirus products is now available from AMSBIO optimized to suit almost any research application. For immunotherapy researchers looking to maximize timelines, AMSBIO can deliver ready-to-transduce CAR lentivirus of up to 10e9 IFU/ml.

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