Validated Tumor Tissue Samples for Cancer Research

CancerSeq™ FFPE tissues from AMSBIO are pre-screened tumor tissue samples for single nucleotide polymorphisms (SNP’s), insertions and deletions plus copy number variations (CNVs) using targeted Next Generation Sequencing to identify key mutations and mutational hotspots.

A major focus of cancer research is gaining insights into the complex mechanisms driving tumor development. While traditional cancer cell lines or genetically altered cell lines are commonly used as in vitro tumor models, they do not capture the diverse genetic variances present in real tumor tissues, which carry multiple mutations rather than just one or two.

CancerSeq™ tissues, derived from real tumor samples, are critical for studying the full complexity of clinical cancer biology. Available as FFPE curls, slides, and blocks, CancerSeq™ samples are prepared from genomic DNA extracted from authentic tumor tissues, enabling researchers to explore cancer in a more accurate and relevant way.

Validated using the most advanced Next Generation Sequencing instruments, CancerSeq™, CancerSeq™ Plus and CancerSeq™ AMS tissue samples are delivered with the mutation and variation data for up to 67 cancer-related genes including BRAF, KRAS, EGFR, ALK and TP53. Additionally, details of the tissue donor clinical histories and tumor type can also be supplied on request.

CancerSeq™ tissue samples are proven in research applications including validation of cancer marker mutation related drug candidates; controls for genotyping; companion diagnostic assay development; IHC and in-situ hybridization assays: cellular localization of tissue specific mRNA and protein expression as well as isolation of DNA and RNA with specific mutation profiles.